Detailed information of TA system TA137126

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-brnA/BrnT_toxin-BrnA
• Location: 1888240..1888771
• Replicon: chromosome
• Accession: NZ_CP043082
• Organism: Bordetella parapertussis strain J297

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: K0MH61
• Locus tag: FYB41_RS08945
• Protein ID: WP_003812626.1
• Coordinates: 1888505..1888771 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: K0MF02
• Locus tag: FYB41_RS08940
• Protein ID: WP_003816743.1
• Coordinates: 1888240..1888518 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB41_RS08910	1883670..1884764	+	1095	WP_003812637.1	TRAP transporter substrate-binding protein	-
FYB41_RS08915	1884976..1885605	+	630	WP_010928293.1	TRAP transporter small permease subunit	-
FYB41_RS08920	1885608..1887275	+	1668	WP_010928294.1	TRAP transporter large permease subunit	-
FYB41_RS08925	1887290..1887946	+	657	WP_010928295.1	phosphoribosylanthranilate isomerase	-
FYB41_RS08940	1888240..1888518	-	279	WP_003816743.1	BrnA antitoxin family protein	Antitoxin
FYB41_RS08945	1888505..1888771	-	267	WP_003812626.1	BrnT family toxin	Toxin
FYB41_RS08950	1889002..1890543	-	1542	WP_010928296.1	M81 family metallopeptidase	-
FYB41_RS08955	1890605..1891483	-	879	WP_041937387.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB41_RS08960	1891880..1892512	+	633	WP_003812619.1	PAS domain-containing protein	-
FYB41_RS08965	1892623..1893333	+	711	WP_003812617.1	aquaporin Z	-
FYB41_RS08970	1893372..1893644	-	273	WP_003812615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (12-86)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10037.47 Da
• Isoelectric Point: 7.9923

>T137126 WP_003812626.1 NZ_CP043082:c1888771-1888505 [Bordetella parapertussis]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Nucleotide

• Length: 267 bp

>T137126 NZ_CP056515:837322-837810 [Citrobacter freundii]
ATGATCTCCGCCCCTGAGCCGCTTCACGCCGGGCATATTCTTACTCCATTCTGCTGTGGCGTGGATTCGATGGATAACTG
GCTGCAACAGCGGGCGATGAAGAACCAGCTTTCCGGCGCGTCCCGCACATTTGTCTGCTGCGACGATGCTAAGGTGATGG
CTTACTATTCGCTGGCCTCCAGCGCGGTAACGACGAATACCGCCTCCGGTCGCTTTCGCCGCAATATGCCCGATCCGATC
CCGGTTGTCGTGCTGGGGCGACTGGCGGTGGATCAATCGCTGCATGGTCGGAGGATCGGGCGGGCGCTGATACGGGATGC
TGGGCTACGGGTAATCCAGGTGGCGGAGACTATCGGCATTCGCGGAATGCTGGTTCATGCCCTGTCGGATGAAGCGCGGG
AATTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCAATGATGCTGATGGTAACGTTGGGGGATTTGGTGGAG
AGTATTTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10412.89 Da
• Isoelectric Point: 10.5548

>AT137126 WP_003816743.1 NZ_CP043082:c1888518-1888240 [Bordetella parapertussis]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Nucleotide

• Length: 279 bp

>AT137126 NZ_CP043082:c1888518-1888240 [Bordetella parapertussis]
ATGAAAAAGCCTGACCCCGAAAAGATTGACCGCGACAACCCCGAATGGACGGACGCGGAATTTCGGCGGGCCAAGCCGGC
CGCCGAAGTACTGCCCGAGTCGGTGCACGCGATGCTCGGCATTCGTCGCCGTGGGCCTCAAAAGACACCCACCAAACAGG
TCGTCACCATCCGGCTATCGCCTGACGTGGTAGAAGCCTTCAAGGCCTCCGGCACCGGTTGGCAGACTCGCGTGGATGCA
GCCCTGCGGGATTGGCTGAAGACGCACCAGCCTGGCTAG

Structures

Toxin

• AlphaFold DB: K0MH61

Antitoxin

• AlphaFold DB: K0MF02