Detailed information of TA system TA137124

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1082522..1083158
• Replicon: chromosome
• Accession: NZ_CP043082
• Organism: Bordetella parapertussis strain J297

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q7W5Z1
• Locus tag: FYB41_RS05100
• Protein ID: WP_010928914.1
• Coordinates: 1082976..1083158 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q7W5Z0
• Locus tag: FYB41_RS05095
• Protein ID: WP_010928915.1
• Coordinates: 1082522..1082914 (-)
• Length: 131 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB41_RS05070	1078178..1078604	-	427	Protein_995	OB-fold domain-containing protein	-
FYB41_RS05075	1078608..1079780	-	1173	WP_010928918.1	thiolase domain-containing protein	-
FYB41_RS05080	1079847..1080206	-	360	WP_010928917.1	hypothetical protein	-
FYB41_RS05085	1080241..1081215	-	975	WP_010928916.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB41_RS05090	1081340..1082249	+	910	Protein_999	LysR family transcriptional regulator	-
FYB41_RS05095	1082522..1082914	-	393	WP_010928915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB41_RS05100	1082976..1083158	-	183	WP_010928914.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB41_RS05110	1083707..1084927	-	1221	WP_010928912.1	ISL3-like element IS1001 family transposase	-
FYB41_RS05120	1085502..1086689	-	1188	WP_010928911.1	MFS transporter	-
FYB41_RS05125	1086907..1087584	-	678	WP_010928910.1	HAD-IA family hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1083707..1084927	1220

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6572.69 Da
• Isoelectric Point: 10.9062

>T137124 WP_010928914.1 NZ_CP043082:c1083158-1082976 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Nucleotide

• Length: 183 bp

>T137124 NZ_CP056515:646529-646849 [Citrobacter freundii]
ATGCAAATCTCAACTGTACCGGCCACGTTGCCGGTTTCGTCACGCCTGTCTCCCGTCCAGGTGTGGCAACAACTGTTAAC
GTATCTACTGGAACACCATTACGGCCTCACACTCAACGACACGCCATTCCACAATGAGTCAGCTATTCGTGAGCACATCG
AAGCGGGAATAACGCTTGCTGATGCGTTGAATTTTCTTGTGGAACGCTATGAACTGATACGCACTGACCGCAAAGGGTTT
ACATGGCAGGAGCAGACACCGTTCCTGACCGCGACCGATATTCTCAGAGCCAGACGAGCTACCGGGTTGATGAATACGTA
A

Antitoxin

Protein

• Length: 131 a.a.
• Molecular weight: 14058.82 Da
• Isoelectric Point: 4.2876

>AT137124 WP_010928915.1 NZ_CP043082:c1082914-1082522 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Nucleotide

• Length: 393 bp

>AT137124 NZ_CP043082:c1082914-1082522 [Bordetella parapertussis]
GTGAAATATCCCATTGCCATTGAACCCGGCAGCGACACGCGCGCCTGGGGAGTCGTTGTTCCTGATCTGCCCGGCTGCTT
TTCCGCAGCGGACGAAGGGATTGATCAAGCAATCGAGAACGCCAAGGAAGCCATTGAGTTGTGGATTGAAACGGCCATCG
ACTCCGGCGCCCCCATTCCTGCGGCAACCAACATAGCCAATCATCAGGCCAATCCTGAGTTCGCCAACTGGATTTGGGCG
ATTGCTGATGTCGATCCTGCAGTCTTGGATGAAACTGTCGAGCGCGTGAACATCACAATCCCGCGCCGAATTCTCAAGCG
CCTGGATGATCGCGCCCGCGCCGCCGGCGAAAGCCGGAGCAGCTACATCGCACATCTCGCCATGACTGCCTGA

Structures

Toxin

• AlphaFold DB: Q7W5Z1

Antitoxin

• AlphaFold DB: Q7W5Z0