Detailed information of TA system TA137114

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1504859..1505520
• Replicon: chromosome
• Accession: NZ_CP043079
• Organism: Bordetella parapertussis strain J324

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYB44_RS07145
• Protein ID: WP_003812073.1
• Coordinates: 1504859..1505284 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYB44_RS07150
• Protein ID: WP_003812071.1
• Coordinates: 1505281..1505520 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB44_RS07125	1500673..1501650	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB44_RS07130	1501671..1502183	-	513	WP_010928017.1	hypothetical protein	-
FYB44_RS07135	1502682..1504187	+	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYB44_RS07140	1504285..1504749	-	465	WP_003812075.1	MarR family transcriptional regulator	-
FYB44_RS07145	1504859..1505284	-	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYB44_RS07150	1505281..1505520	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYB44_RS07155	1505594..1506436	-	843	WP_010928019.1	AraC family transcriptional regulator	-
FYB44_RS07160	1506574..1507119	+	546	WP_010928020.1	peroxidase-related enzyme	-
FYB44_RS07165	1507178..1507690	+	513	WP_003812062.1	redoxin domain-containing protein	-
FYB44_RS07170	1507771..1508004	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYB44_RS07175	1508001..1508561	+	561	WP_010928021.1	DUF488 domain-containing protein	-
FYB44_RS07180	1508639..1509685	+	1047	WP_010928022.1	Dyp-type peroxidase	-
FYB44_RS07185	1509682..1510485	+	804	WP_003812055.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T137114 WP_003812073.1 NZ_CP043079:c1505284-1504859 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T137114 NZ_CP043079:c1505284-1504859 [Bordetella parapertussis]
ATGATCCTGCTCGACACCGACGTGCTGCTCGAGCCGCTGCGGCCGGCCCCCGACCCGGCCGTCGCGGCATGGCTGGATGC
CCAGCACGTCGAAACCCTGTACCTGGCCGCGCCCGGCGCGGCCGAAATCCAGCTCGGGCTGGCCCGCCTGCCGCGCGGCA
AGCGGGCCGAGGCCTTGCGCCACGAATTCGAGCGGCGCGTCCTGCCGCTGTTCATGGGCCATGTCCTGCCCTTCGACACG
GCCGCGGCCGATGCCTACGCCGCCGTCATGATGCGGGCCGCGGCGGCGGGCCATGCGCTGTGCGCAATCGATGGTTGCAT
CGCCGCCATCGCCACCGCGCACGGCCTGGCCATCGCCACGCGCCATCCGGCCAGGTTCGAGGCGGCCGGGCTCGCCGCCG
TCGATCCCTGGCACGCCGCCGCTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT137114 WP_003812071.1 NZ_CP043079:c1505520-1505281 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT137114 NZ_CP056505:3836772-3837146 [Citrobacter freundii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Toxin

• AlphaFold DB: Q7WAH5