Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 3381730..3382366 | Replicon | chromosome |
Accession | NZ_CP043073 | ||
Organism | Bordetella parapertussis strain J593 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | Q7W5Z1 |
Locus tag | FYB50_RS15980 | Protein ID | WP_010928914.1 |
Coordinates | 3381730..3381912 (+) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | Q7W5Z0 |
Locus tag | FYB50_RS15985 | Protein ID | WP_010928915.1 |
Coordinates | 3381974..3382366 (+) | Length | 131 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FYB50_RS15955 | 3377304..3377981 | + | 678 | WP_010928910.1 | HAD-IA family hydrolase | - |
FYB50_RS15960 | 3378199..3379386 | + | 1188 | WP_010928911.1 | MFS transporter | - |
FYB50_RS15970 | 3379961..3381181 | + | 1221 | WP_010928912.1 | ISL3-like element IS1001 family transposase | - |
FYB50_RS15980 | 3381730..3381912 | + | 183 | WP_010928914.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
FYB50_RS15985 | 3381974..3382366 | + | 393 | WP_010928915.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
FYB50_RS15990 | 3382639..3383548 | - | 910 | Protein_3139 | LysR family transcriptional regulator | - |
FYB50_RS15995 | 3383673..3384647 | + | 975 | WP_010928916.1 | tripartite tricarboxylate transporter substrate binding protein | - |
FYB50_RS16000 | 3384682..3385041 | + | 360 | WP_010928917.1 | hypothetical protein | - |
FYB50_RS16005 | 3385108..3386280 | + | 1173 | WP_010928918.1 | thiolase domain-containing protein | - |
FYB50_RS16010 | 3386284..3386710 | + | 427 | Protein_3143 | OB-fold domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 3379961..3381181 | 1220 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6572.69 Da Isoelectric Point: 10.9062
>T137088 WP_010928914.1 NZ_CP043073:3381730-3381912 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK
Download Length: 183 bp
>T137088 NZ_CP056466:672419-672760 [Citrobacter freundii]
ATGAAACCTCAACCTGCAACAACTTCGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGACAGTCTGGCAAATGCTGCTGAC
CCGATTGTTCGAAAAACACTATGGCCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTGCGTATCGACAGGAATGGATTT
ATCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCATAACAACGCAATACGTTGA
ATGAAACCTCAACCTGCAACAACTTCGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGACAGTCTGGCAAATGCTGCTGAC
CCGATTGTTCGAAAAACACTATGGCCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTGCGTATCGACAGGAATGGATTT
ATCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCATAACAACGCAATACGTTGA
Antitoxin
Download Length: 131 a.a. Molecular weight: 14058.82 Da Isoelectric Point: 4.2876
>AT137088 WP_010928915.1 NZ_CP043073:3381974-3382366 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA
Download Length: 393 bp
>AT137088 NZ_CP056466:672081-672398 [Citrobacter freundii]
ATGACCTACATCACATGGGGCCTGCAGCGGAATATCACGCCGCGTCTGGGAGCCCGTCTGGTGCAGGAGGGCAACCGGCT
GCATTATCTGGCTGACCGGGGCAGTATCACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTATCAC
AATGGTTTTACCTGCGAAGCCGATACCTTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
ATGACCTACATCACATGGGGCCTGCAGCGGAATATCACGCCGCGTCTGGGAGCCCGTCTGGTGCAGGAGGGCAACCGGCT
GCATTATCTGGCTGACCGGGGCAGTATCACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTATCAC
AATGGTTTTACCTGCGAAGCCGATACCTTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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