Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3381753..3382389 Replicon chromosome
Accession NZ_CP043070
Organism Bordetella parapertussis strain J611

Toxin (Protein)


Gene name hicA Uniprot ID Q7W5Z1
Locus tag FYB53_RS15975 Protein ID WP_010928914.1
Coordinates 3381753..3381935 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q7W5Z0
Locus tag FYB53_RS15980 Protein ID WP_010928915.1
Coordinates 3381997..3382389 (+) Length 131 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYB53_RS15950 3377327..3378004 + 678 WP_010928910.1 HAD-IA family hydrolase -
FYB53_RS15955 3378222..3379409 + 1188 WP_010928911.1 MFS transporter -
FYB53_RS15965 3379984..3381204 + 1221 WP_010928912.1 ISL3-like element IS1001 family transposase -
FYB53_RS15975 3381753..3381935 + 183 WP_010928914.1 type II toxin-antitoxin system HicA family toxin Toxin
FYB53_RS15980 3381997..3382389 + 393 WP_010928915.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FYB53_RS15985 3382662..3383571 - 910 Protein_3138 LysR family transcriptional regulator -
FYB53_RS15990 3383696..3384670 + 975 WP_010928916.1 tripartite tricarboxylate transporter substrate binding protein -
FYB53_RS15995 3384705..3385064 + 360 WP_010928917.1 hypothetical protein -
FYB53_RS16000 3385131..3386303 + 1173 WP_010928918.1 thiolase domain-containing protein -
FYB53_RS16005 3386307..3386733 + 427 Protein_3142 OB-fold domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3379984..3381204 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6572.69 Da        Isoelectric Point: 10.9062

>T137073 WP_010928914.1 NZ_CP043070:3381753-3381935 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Download         Length: 183 bp

>T137073 NZ_CP056451:c4330745-4330461 [Citrobacter freundii]
ATGACTTATGAACTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATAAGGTGAAGGCTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCAGATTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGATCGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCGGCCGTTTATCTCGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14058.82 Da        Isoelectric Point: 4.2876

>AT137073 WP_010928915.1 NZ_CP043070:3381997-3382389 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Download         Length: 393 bp

>AT137073 NZ_CP043070:3381997-3382389 [Bordetella parapertussis]
GTGAAATATCCCATTGCCATTGAACCCGGCAGCGACACGCGCGCCTGGGGAGTCGTTGTTCCTGATCTGCCCGGCTGCTT
TTCCGCAGCGGACGAAGGGATTGATCAAGCAATCGAGAACGCCAAGGAAGCCATTGAGTTGTGGATTGAAACGGCCATCG
ACTCCGGCGCCCCCATTCCTGCGGCAACCAACATAGCCAATCATCAGGCCAATCCTGAGTTCGCCAACTGGATTTGGGCG
ATTGCTGATGTCGATCCTGCAGTCTTGGATGAAACTGTCGAGCGCGTGAACATCACAATCCCGCGCCGAATTCTCAAGCG
CCTGGATGATCGCGCCCGCGCCGCCGGCGAAAGCCGGAGCAGCTACATCGCACATCTCGCCATGACTGCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q7W5Z1


Antitoxin

Source ID Structure
AlphaFold DB Q7W5Z0

References