Detailed information of TA system TA137070

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): shpA-brnA/BrnT_toxin-BrnA
• Location: 2091519..2092050
• Replicon: chromosome
• Accession: NZ_CP043070
• Organism: Bordetella parapertussis strain J611

Toxin (Protein)

• Gene name: shpA
• Uniprot ID: K0MH61
• Locus tag: FYB53_RS09980
• Protein ID: WP_003812626.1
• Coordinates: 2091784..2092050 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: K0MF02
• Locus tag: FYB53_RS09975
• Protein ID: WP_003816743.1
• Coordinates: 2091519..2091797 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB53_RS09945	2086949..2088043	+	1095	WP_003812637.1	TRAP transporter substrate-binding protein	-
FYB53_RS09950	2088255..2088884	+	630	WP_010928293.1	TRAP transporter small permease subunit	-
FYB53_RS09955	2088887..2090554	+	1668	WP_010928294.1	TRAP transporter large permease subunit	-
FYB53_RS09960	2090569..2091225	+	657	WP_010928295.1	phosphoribosylanthranilate isomerase	-
FYB53_RS09975	2091519..2091797	-	279	WP_003816743.1	BrnA antitoxin family protein	Antitoxin
FYB53_RS09980	2091784..2092050	-	267	WP_003812626.1	BrnT family toxin	Toxin
FYB53_RS09985	2092281..2093822	-	1542	WP_010928296.1	M81 family metallopeptidase	-
FYB53_RS09990	2093884..2094762	-	879	WP_041937387.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB53_RS09995	2095159..2095791	+	633	WP_003812619.1	PAS domain-containing protein	-
FYB53_RS10000	2095902..2096612	+	711	WP_003812617.1	aquaporin Z	-
FYB53_RS10005	2096651..2096923	-	273	WP_003812615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (12-86)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10037.47 Da
• Isoelectric Point: 7.9923

>T137070 WP_003812626.1 NZ_CP043070:c2092050-2091784 [Bordetella parapertussis]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Nucleotide

• Length: 267 bp

>T137070 NZ_CP043070:c2092050-2091784 [Bordetella parapertussis]
ATGGATATCACCTACGACCCCGCCAAGAACGACAAGAACATTGCCGATCGCGGCCTGTCGTTCGAGTTGGTGTGTGGCTT
CGAGTGGGCCAGCGCGCTGGTGGTTGAGGATACCCGCCAGGTCTACGCCGAAACGCGCTATCAGGCGCTGGGCAAAATCG
ATGGCCGGCTCCATATGGTGGTATTCACGGTGCGCGGCGAGTCGCTGCGCATCATCAGCCTGCGTAAGGCAAATGCTCGT
GAGGTAGCTCGTTATGAAAAAGCCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10412.89 Da
• Isoelectric Point: 10.5548

>AT137070 WP_003816743.1 NZ_CP043070:c2091797-2091519 [Bordetella parapertussis]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Nucleotide

• Length: 279 bp

>AT137070 NZ_CP056451:3698112-3698486 [Citrobacter freundii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Toxin

• AlphaFold DB: K0MH61

Antitoxin

• AlphaFold DB: K0MF02