Detailed information of TA system TA137069

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1504869..1505530
• Replicon: chromosome
• Accession: NZ_CP043070
• Organism: Bordetella parapertussis strain J611

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYB53_RS07140
• Protein ID: WP_003812073.1
• Coordinates: 1504869..1505294 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYB53_RS07145
• Protein ID: WP_003812071.1
• Coordinates: 1505291..1505530 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB53_RS07120	1500683..1501660	+	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB53_RS07125	1501681..1502193	-	513	WP_010928017.1	hypothetical protein	-
FYB53_RS07130	1502692..1504197	+	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYB53_RS07135	1504295..1504759	-	465	WP_003812075.1	MarR family transcriptional regulator	-
FYB53_RS07140	1504869..1505294	-	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYB53_RS07145	1505291..1505530	-	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYB53_RS07150	1505604..1506446	-	843	WP_010928019.1	AraC family transcriptional regulator	-
FYB53_RS07155	1506584..1507129	+	546	WP_010928020.1	peroxidase-related enzyme	-
FYB53_RS07160	1507188..1507700	+	513	WP_003812062.1	redoxin domain-containing protein	-
FYB53_RS07165	1507781..1508014	+	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYB53_RS07170	1508011..1508571	+	561	WP_010928021.1	DUF488 domain-containing protein	-
FYB53_RS07175	1508649..1509695	+	1047	WP_010928022.1	Dyp-type peroxidase	-
FYB53_RS07180	1509692..1510495	+	804	WP_003812055.1	bacteriocin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T137069 WP_003812073.1 NZ_CP043070:c1505294-1504869 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T137069 NZ_CP056451:c2530855-2530577 [Citrobacter freundii]
ATGATCATGAACTTCAGACACAAGGGATTGCGAGATTTGTTTCTTCATGGAAGAACATCAGGCGTTATGGCGAAACATGT
CCGACGATTACGACACAGGCTTGCCGTTATTGATGCGGCAAGCAAGGTTACAGATATCAATATGCCCGGTTATAAGCTAC
ATCCTCTGGTAGGTGACCGTGATGGCATATGGGCAATAACTGTTTCAGGTAACTGGCGTATTACGTTTGAATTCGTCAAT
GGCGACGCGTACATACTGGACTACGAGGACTATCATTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT137069 WP_003812071.1 NZ_CP043070:c1505530-1505291 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT137069 NZ_CP056451:c2530577-2530293 [Citrobacter freundii]
ATGAAGATGGCAAATCATCCCCGTCCTGGGGATATCATTCAGGAAGCGCTGGAAGAACTCAATGTCAGCCTGCGCGAGTT
TGCCAGAGCTATGGAGATTGCACCTTCAACGGCAAGTCGACTATTAACCGGGAAAGCAGCCCTAACGCCTGAGATGGCGA
TTAAACTCTCTGTGGTGATTGGCAGCTCACCCGAAATGTGGTTAAACCTGCAAACTACCTGGAGTCTGGCAGAGGCCCAA
AAAAGCGTGGATATTTCACGCCTGCGTAAGCTGGCAGTACAGTGA

Structures

Toxin

• AlphaFold DB: Q7WAH5