Detailed information of TA system TA137056

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2225687..2226281
• Replicon: chromosome
• Accession: NZ_CP043064
• Organism: Bordetella parapertussis strain J786

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: FYB62_RS10620
• Protein ID: WP_010928352.1
• Coordinates: 2226099..2226281 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: FYB62_RS10615
• Protein ID: WP_010928351.1
• Coordinates: 2225687..2226076 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB62_RS10590	2221530..2222570	+	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-
FYB62_RS10595	2222705..2223721	+	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
FYB62_RS10600	2223743..2224600	+	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
FYB62_RS10605	2224645..2225421	+	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
FYB62_RS10615	2225687..2226076	-	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB62_RS10620	2226099..2226281	-	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB62_RS10625	2226689..2227387	+	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
FYB62_RS10630	2227391..2229160	+	1770	WP_010928353.1	GMC family oxidoreductase	-
FYB62_RS10635	2229171..2230526	+	1356	WP_003809657.1	cytochrome c	-
FYB62_RS10640	2230538..2231278	-	741	WP_003809659.1	carbonic anhydrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T137056 WP_010928352.1 NZ_CP043064:c2226281-2226099 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T137056 NZ_CP043064:c2226281-2226099 [Bordetella parapertussis]
ATGAACAGCACAGACCTGATCCAGCAACCGAAGGCCGACGGCTGGTATCGCGTGCATACCGTGGGTTCACACCACCAGTA
CAAGCACCCGACCAAGCCCGGCAAGGTCACCGTGCCGCATCCCAGGAAGGGCCTGCCGACAGCGACACAGCGCAGCATCC
TTAAGCAAGCCGGCCTGCGATAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT137056 WP_010928351.1 NZ_CP043064:c2226076-2225687 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT137056 NZ_CP056432:c4752297-4752055 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7