Detailed information of TA system TA137051

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2225713..2226307
• Replicon: chromosome
• Accession: NZ_CP043063
• Organism: Bordetella parapertussis strain J792

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: K0M8J0
• Locus tag: FYB64_RS10620
• Protein ID: WP_010928352.1
• Coordinates: 2226125..2226307 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: K0MFV7
• Locus tag: FYB64_RS10615
• Protein ID: WP_010928351.1
• Coordinates: 2225713..2226102 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB64_RS10590	2221556..2222596	+	1041	WP_003809635.1	phosphate ABC transporter substrate-binding protein PstS	-
FYB64_RS10595	2222731..2223747	+	1017	WP_010928350.1	phosphate ABC transporter permease subunit PstC	-
FYB64_RS10600	2223769..2224626	+	858	WP_003809638.1	phosphate ABC transporter permease PstA	-
FYB64_RS10605	2224671..2225447	+	777	WP_033448479.1	phosphate ABC transporter ATP-binding protein PstB	-
FYB64_RS10615	2225713..2226102	-	390	WP_010928351.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FYB64_RS10620	2226125..2226307	-	183	WP_010928352.1	type II toxin-antitoxin system HicA family toxin	Toxin
FYB64_RS10625	2226715..2227413	+	699	WP_003809653.1	gluconate 2-dehydrogenase subunit 3 family protein	-
FYB64_RS10630	2227417..2229186	+	1770	WP_010928353.1	GMC family oxidoreductase	-
FYB64_RS10635	2229197..2230552	+	1356	WP_003809657.1	cytochrome c	-
FYB64_RS10640	2230564..2231304	-	741	WP_003809659.1	carbonic anhydrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6750.76 Da
• Isoelectric Point: 11.4018

>T137051 WP_010928352.1 NZ_CP043063:c2226307-2226125 [Bordetella parapertussis]
MNSTDLIQQPKADGWYRVHTVGSHHQYKHPTKPGKVTVPHPRKGLPTATQRSILKQAGLR

Nucleotide

• Length: 183 bp

>T137051 NZ_CP056432:1848424-1848526 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14270.92 Da
• Isoelectric Point: 4.3014

>AT137051 WP_010928351.1 NZ_CP043063:c2226102-2225713 [Bordetella parapertussis]
MLYPIHVSKDEGSAYGAAFPDFPGCFAAADELQDLPRAAQEAVEAHFYGETERIPAPSAPEAWANDEDYQGGYWMMVDID
LSKVNTKAVRLNISLPENLVHRIDEEAKARRLSRSAFLAMAAEHEMADA

Nucleotide

• Length: 390 bp

>AT137051 NZ_CP043063:c2226102-2225713 [Bordetella parapertussis]
ATGCTCTACCCGATCCATGTTTCCAAAGACGAAGGCAGCGCCTACGGGGCCGCCTTCCCTGATTTTCCCGGCTGCTTTGC
AGCCGCCGATGAACTCCAGGACCTCCCCCGCGCGGCGCAGGAAGCCGTTGAGGCGCACTTCTACGGAGAGACCGAGCGTA
TCCCCGCCCCGTCCGCCCCTGAAGCGTGGGCCAACGATGAGGACTATCAAGGCGGCTATTGGATGATGGTCGATATCGAC
CTGTCGAAGGTCAACACGAAGGCCGTGCGGCTCAACATCAGCCTGCCGGAAAACCTGGTTCACCGTATCGACGAGGAAGC
CAAGGCACGACGCCTTTCGCGCTCAGCGTTTCTGGCCATGGCTGCGGAGCACGAAATGGCCGACGCCTAG

Structures

Toxin

• AlphaFold DB: K0M8J0

Antitoxin

• AlphaFold DB: K0MFV7