Detailed information of TA system TA137047

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 3161960..3162621
• Replicon: chromosome
• Accession: NZ_CP043062
• Organism: Bordetella parapertussis strain J835

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q7WAH5
• Locus tag: FYB65_RS14975
• Protein ID: WP_003812073.1
• Coordinates: 3162196..3162621 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FYB65_RS14970
• Protein ID: WP_003812071.1
• Coordinates: 3161960..3162199 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB65_RS14935	3156995..3157798	-	804	WP_003812055.1	bacteriocin family protein	-
FYB65_RS14940	3157795..3158841	-	1047	WP_010928022.1	Dyp-type peroxidase	-
FYB65_RS14945	3158919..3159479	-	561	WP_010928021.1	DUF488 domain-containing protein	-
FYB65_RS14950	3159476..3159709	-	234	WP_033447224.1	DUF2945 domain-containing protein	-
FYB65_RS14955	3159790..3160302	-	513	WP_003812062.1	redoxin domain-containing protein	-
FYB65_RS14960	3160361..3160906	-	546	WP_010928020.1	peroxidase-related enzyme	-
FYB65_RS14965	3161044..3161886	+	843	WP_010928019.1	AraC family transcriptional regulator	-
FYB65_RS14970	3161960..3162199	+	240	WP_003812071.1	Arc family DNA-binding protein	Antitoxin
FYB65_RS14975	3162196..3162621	+	426	WP_003812073.1	PIN domain-containing protein	Toxin
FYB65_RS14980	3162731..3163195	+	465	WP_003812075.1	MarR family transcriptional regulator	-
FYB65_RS14985	3163293..3164798	-	1506	WP_010928018.1	tripartite tricarboxylate transporter permease	-
FYB65_RS14990	3165297..3165809	+	513	WP_010928017.1	hypothetical protein	-
FYB65_RS14995	3165830..3166807	-	978	WP_003812083.1	tripartite tricarboxylate transporter substrate binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-121)

Antitoxin

• Arc-like DNA binding domain (9-46)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 14811.22 Da
• Isoelectric Point: 6.3704

>T137047 WP_003812073.1 NZ_CP043062:3162196-3162621 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Nucleotide

• Length: 426 bp

>T137047 NZ_CP056426:c175380-175093 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8561.78 Da
• Isoelectric Point: 11.5658

>AT137047 WP_003812071.1 NZ_CP043062:3161960-3162199 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Nucleotide

• Length: 240 bp

>AT137047 NZ_CP056426:c175619-175380 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: Q7WAH5