Detailed information of TA system TA137038

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 5286671..5287713
• Replicon: chromosome
• Accession: NZ_CP043060
• Organism: Pseudomonas sp. J380

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: A0A4Q0HSC5
• Locus tag: FXO12_RS24180
• Protein ID: WP_054922014.1
• Coordinates: 5287138..5287713 (+)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: FXO12_RS24175
• Protein ID: WP_054922011.1
• Coordinates: 5286671..5287141 (+)
• Length: 157 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXO12_RS24140	5282386..5283000	-	615	WP_054922006.1	biliverdin-producing heme oxygenase	-
FXO12_RS24145	5283213..5283575	-	363	WP_003194033.1	response regulator	-
FXO12_RS24150	5283738..5284169	+	432	WP_054897818.1	VOC family protein	-
FXO12_RS24155	5284200..5284574	+	375	WP_034128041.1	cytochrome c family protein	-
FXO12_RS24160	5284660..5285002	-	343	Protein_4759	barstar family protein	-
FXO12_RS24165	5285058..5285315	-	258	WP_082430498.1	colicin transporter	-
FXO12_RS24170	5285323..5286477	-	1155	WP_057975058.1	S-type pyocin domain-containing protein	-
FXO12_RS24175	5286671..5287141	+	471	WP_054922011.1	helix-turn-helix domain-containing protein	Antitoxin
FXO12_RS24180	5287138..5287713	+	576	WP_054922014.1	PIN domain-containing protein	Toxin
FXO12_RS24185	5287794..5288165	-	372	WP_014719840.1	PH domain-containing protein	-
FXO12_RS24190	5288322..5288957	+	636	WP_054897816.1	LysE family translocator	-
FXO12_RS24195	5288965..5289294	-	330	WP_054897815.1	hypothetical protein	-
FXO12_RS24205	5289571..5290620	+	1050	WP_034128030.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
FXO12_RS24210	5290626..5291741	+	1116	WP_032803964.1	tRNA guanosine(34) transglycosylase Tgt	-
FXO12_RS24215	5291785..5292123	+	339	WP_003175975.1	preprotein translocase subunit YajC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-115)

Antitoxin

• Helix-turn-helix domain, group 17 (84-132)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21375.75 Da
• Isoelectric Point: 4.7036

>T137038 WP_054922014.1 NZ_CP043060:5287138-5287713 [Pseudomonas sp. J380]
MRCSPFTAVYDACVLYPAALRDLLMWLGLSGLYRARWTAQIQDEWKRNVLKNRPDLTAAQVDCTSALMDIAIPDALVTGY
EDLCSSLDLPDPDDRHVLAAAIRSKAEVIVTFNLKDFPPHVLAAYDIEPMHPDDFISDLWDLDQAAVLGAAQKQRRALKK
PAMEAGSYLEMLMRQGLVQTSKAMGPYEMML

Nucleotide

• Length: 576 bp

>T137038 NZ_CP056425:1880003-1880105 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 157 a.a.
• Molecular weight: 17482.15 Da
• Isoelectric Point: 6.1085

>AT137038 WP_054922011.1 NZ_CP043060:5286671-5287141 [Pseudomonas sp. J380]
MTINNLPKTILPLEKEVEAAVQGQRELASLLSTKFETQRIDIFDKEDKPHRLVLPTSALRLLVDILGELALGNAVKVVPV
HAELTSQEAADLLNVSRPHLVKMLEDGAIPFTKTGRHRRVRFSDLMAFKQRRDEQSQEAMEALVQQAQELGMGYDG

Nucleotide

• Length: 471 bp

>AT137038 NZ_CP043060:5286671-5287141 [Pseudomonas sp. J380]
ATGACCATCAACAACCTTCCAAAAACGATCCTTCCGCTGGAAAAAGAAGTCGAGGCGGCAGTGCAAGGCCAGCGTGAATT
AGCGTCCCTATTGTCGACCAAATTTGAAACCCAGCGCATCGACATCTTCGACAAAGAAGATAAGCCACACAGGCTTGTAC
TCCCAACCTCCGCACTGCGCCTGCTGGTCGATATTCTGGGCGAATTGGCGCTCGGCAATGCCGTCAAGGTAGTGCCGGTT
CATGCCGAGTTGACCTCGCAGGAGGCGGCCGACCTGCTTAATGTGTCACGCCCGCATTTGGTCAAAATGCTCGAGGACGG
CGCTATCCCTTTTACAAAAACGGGTCGACATCGGCGAGTCCGCTTTTCGGATTTGATGGCGTTCAAGCAACGGCGTGACG
AGCAAAGCCAAGAGGCAATGGAAGCGCTGGTTCAACAGGCCCAGGAGTTGGGAATGGGGTATGACGGATGA

Structures

Toxin

• AlphaFold DB: A0A4Q0HSC5