Detailed information of TA system TA137037

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4709653..4710291
• Replicon: chromosome
• Accession: NZ_CP043060
• Organism: Pseudomonas sp. J380

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FXO12_RS21330
• Protein ID: WP_082631615.1
• Coordinates: 4709653..4709838 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0R3BJQ1
• Locus tag: FXO12_RS21335
• Protein ID: WP_034133907.1
• Coordinates: 4709890..4710291 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXO12_RS21315	4706275..4707069	-	795	WP_057976574.1	carbon-nitrogen hydrolase family protein	-
FXO12_RS21320	4707080..4708783	-	1704	WP_057976576.1	NAD(P)/FAD-dependent oxidoreductase	-
FXO12_RS21325	4708931..4709377	-	447	WP_003194755.1	Lrp/AsnC family transcriptional regulator	-
FXO12_RS21330	4709653..4709838	+	186	WP_082631615.1	type II toxin-antitoxin system HicA family toxin	Toxin
FXO12_RS21335	4709890..4710291	+	402	WP_034133907.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FXO12_RS21340	4710950..4712518	+	1569	WP_160049814.1	hypothetical protein	-
FXO12_RS21345	4712580..4713446	+	867	WP_160049741.1	DNA adenine methylase	-
FXO12_RS21350	4713854..4714141	+	288	WP_160049742.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6758.90 Da
• Isoelectric Point: 11.0837

>T137037 WP_082631615.1 NZ_CP043060:4709653-4709838 [Pseudomonas sp. J380]
MRSREVIELLVADGWVEVAVKGSHHQFKHPVKRGRVTVPHPKSAIATGTLHSIFKSAGLKY

Nucleotide

• Length: 186 bp

>T137037 NZ_CP043060:4709653-4709838 [Pseudomonas sp. J380]
ATGAGAAGTAGAGAGGTCATTGAGCTGCTGGTTGCGGATGGATGGGTTGAGGTGGCGGTAAAGGGTAGTCATCACCAGTT
CAAACACCCAGTGAAGCGAGGACGAGTAACAGTCCCTCACCCTAAGTCAGCGATTGCTACGGGCACCTTGCACAGTATTT
TTAAATCGGCAGGGCTTAAATATTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14639.37 Da
• Isoelectric Point: 4.5253

>AT137037 WP_034133907.1 NZ_CP043060:4709890-4710291 [Pseudomonas sp. J380]
MKFPVVVHKDADSDYSVTVPDVPGCFSAGSSFSEALDNVREALALHLEGLVADEEKLPQAQEVDAHLDNPDFTGGVWAIV
DFDLTPYLGKSVRFNASLPEQLLHRIDERVQKDHRYASRSGFLATAALRELSV

Nucleotide

• Length: 402 bp

>AT137037 NZ_CP043060:4709890-4710291 [Pseudomonas sp. J380]
ATGAAATTTCCAGTGGTAGTGCATAAAGACGCTGATTCGGACTACAGCGTAACGGTCCCTGACGTACCAGGCTGCTTCTC
GGCGGGCTCTTCGTTTTCCGAAGCGTTAGATAATGTTCGGGAGGCGCTGGCGCTGCACCTTGAAGGATTGGTTGCCGACG
AGGAAAAACTTCCCCAGGCCCAAGAGGTTGATGCTCATCTTGATAATCCCGACTTCACCGGTGGTGTCTGGGCGATCGTC
GACTTCGACCTCACGCCTTACTTGGGGAAATCGGTACGGTTCAACGCTTCTTTACCCGAGCAGCTTTTGCATCGAATTGA
CGAGCGTGTGCAAAAGGATCATCGCTACGCCTCGCGTTCAGGTTTTTTGGCGACGGCAGCGCTGCGCGAATTGTCTGTTT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0R3BJQ1