Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2270404..2270926 Replicon chromosome
Accession NZ_CP043060
Organism Pseudomonas sp. J380

Toxin (Protein)


Gene name relE Uniprot ID A0A7Y0Z9L4
Locus tag FXO12_RS10135 Protein ID WP_034126587.1
Coordinates 2270633..2270926 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0W0N4Z1
Locus tag FXO12_RS10130 Protein ID WP_014717442.1
Coordinates 2270404..2270643 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXO12_RS10110 2265896..2267212 - 1317 WP_057975666.1 MHS family MFS transporter -
FXO12_RS10115 2267370..2268311 + 942 WP_034126590.1 LysR family transcriptional regulator -
FXO12_RS10120 2268445..2269671 + 1227 WP_057975665.1 MFS transporter -
FXO12_RS10125 2269744..2269998 - 255 WP_019818461.1 hypothetical protein -
FXO12_RS10130 2270404..2270643 + 240 WP_014717442.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FXO12_RS10135 2270633..2270926 + 294 WP_034126587.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FXO12_RS10140 2271155..2272756 + 1602 WP_160049615.1 tyrosine-type recombinase/integrase -
FXO12_RS10145 2272968..2273792 + 825 WP_124399794.1 GIY-YIG nuclease family protein -
FXO12_RS10150 2273837..2274586 + 750 WP_122767689.1 abortive infection family protein -
FXO12_RS10155 2274611..2275018 - 408 WP_177324604.1 hypothetical protein -
FXO12_RS10160 2275087..2275623 - 537 WP_138739343.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2270404..2352090 81686


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11490.26 Da        Isoelectric Point: 10.0984

>T137036 WP_034126587.1 NZ_CP043060:2270633-2270926 [Pseudomonas sp. J380]
MTYSLDFDARALKEWQKLGDTLRQQLKKKLVEVLNNPRIEANRLHGLPDCYKIKLHSSGYRLVYQVIDQEVTVFVVAVDK
RERDQAYRKASERLVQR

Download         Length: 294 bp

>T137036 NZ_CP056425:797433-797918 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGTGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8997.40 Da        Isoelectric Point: 4.6017

>AT137036 WP_014717442.1 NZ_CP043060:2270404-2270643 [Pseudomonas sp. J380]
MASINIRIDDDLKARAYLELEKLGVTPSELIRQALQYVAERGQLPFKPVLMTEEDEALMATVRERLASPQRVRVSLDDL

Download         Length: 240 bp

>AT137036 NZ_CP043060:2270404-2270643 [Pseudomonas sp. J380]
TTGGCATCTATCAACATCCGTATCGATGACGACCTGAAAGCTCGTGCCTACCTAGAGCTGGAGAAACTCGGTGTCACACC
TTCTGAACTGATACGTCAGGCGTTGCAATATGTTGCCGAACGCGGCCAGTTGCCATTTAAGCCTGTGCTGATGACTGAAG
AGGATGAAGCCTTGATGGCGACCGTACGTGAGCGTCTTGCATCGCCTCAACGCGTAAGGGTTTCTTTGGATGACCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Y0Z9L4

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0N4Z1

References