Detailed information of TA system TA137035

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 1538502..1539115
• Replicon: chromosome
• Accession: NZ_CP043060
• Organism: Pseudomonas sp. J380

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FXO12_RS06785
• Protein ID: WP_057977120.1
• Coordinates: 1538502..1538753 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A854B833
• Locus tag: FXO12_RS06790
• Protein ID: WP_014718824.1
• Coordinates: 1538750..1539115 (+)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXO12_RS06785	1538502..1538753	+	252	WP_057977120.1	type II toxin-antitoxin system HicA family toxin	Toxin
FXO12_RS06790	1538750..1539115	+	366	WP_014718824.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FXO12_RS06795	1539116..1540288	-	1173	WP_054897054.1	MFS transporter	-
FXO12_RS06800	1540421..1541008	+	588	WP_054897053.1	TetR/AcrR family transcriptional regulator	-
FXO12_RS06805	1540992..1542347	-	1356	WP_054897052.1	MATE family efflux transporter	-
FXO12_RS06810	1542367..1542939	-	573	WP_054897051.1	DUF2239 family protein	-
FXO12_RS06815	1543465..1543983	+	519	WP_082423389.1	PAAR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9512.08 Da
• Isoelectric Point: 10.0459

>T137035 WP_057977120.1 NZ_CP043060:1538502-1538753 [Pseudomonas sp. J380]
VSKNEKLLAKLLNEHMAFTWSELVTLLRRLGYTQIEGAGSRVKFDMGDPSAMISLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Nucleotide

• Length: 252 bp

>T137035 NZ_CP056425:379399-379767 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGTGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13248.12 Da
• Isoelectric Point: 7.3725

>AT137035 WP_014718824.1 NZ_CP043060:1538750-1539115 [Pseudomonas sp. J380]
VNNQLKHKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFRGAVDDYLATCQSLGHTPEKPCKGSFNVRVGH
DLHLAAALAANRKKVTLNDLTRQALNEFLQHHYPEPCPTIG

Nucleotide

• Length: 366 bp

>AT137035 NZ_CP043060:1538750-1539115 [Pseudomonas sp. J380]
GTGAACAACCAACTGAAACACAAAGGCTACATCGGCTCCATCGAAGCCAGCCTCGAGGACAACTGCCTGTTTGGTAAAAT
CCTGTTCATCAAGGCATTGGTGAGCTATGAAGGCAAAACTGTGGCTGAACTGGACGCAGCCTTCCGTGGCGCGGTGGATG
ATTATCTCGCTACCTGCCAGAGCCTGGGGCACACGCCGGAGAAACCGTGCAAAGGTTCATTCAACGTACGCGTCGGGCAT
GACTTGCATTTGGCCGCTGCCCTGGCGGCAAACCGTAAGAAAGTGACATTGAATGATCTCACGCGTCAGGCGCTGAACGA
ATTTCTGCAGCATCACTACCCAGAGCCATGCCCGACGATTGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A854B833