Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1306179..1306871 Replicon chromosome
Accession NZ_CP043056
Organism Dolichospermum sp. UHCC 0315A

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BMF77_RS05965 Protein ID WP_148761411.1
Coordinates 1306611..1306871 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BMF77_RS05960 Protein ID WP_148761409.1
Coordinates 1306179..1306517 (-) Length 113 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMF77_RS05935 1301413..1302504 + 1092 WP_148761401.1 spermidine/putrescine ABC transporter substrate-binding protein -
BMF77_RS05940 1302686..1303567 + 882 WP_148761403.1 ABC transporter permease -
BMF77_RS05950 1303967..1305073 + 1107 WP_148761405.1 Gfo/Idh/MocA family oxidoreductase -
BMF77_RS05955 1305469..1306062 - 594 WP_148761407.1 hypothetical protein -
BMF77_RS05960 1306179..1306517 - 339 WP_148761409.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BMF77_RS05965 1306611..1306871 - 261 WP_148761411.1 type II toxin-antitoxin system HicA family toxin Toxin
BMF77_RS05970 1307220..1307438 - 219 WP_210422304.1 cobaltochelatase subunit CobN -
BMF77_RS05975 1307574..1307825 + 252 WP_148761413.1 type II toxin-antitoxin system ParD family antitoxin -
BMF77_RS05980 1307828..1307983 + 156 WP_148761415.1 type II toxin-antitoxin system RelE/ParE family toxin -
BMF77_RS05985 1308025..1308336 - 312 WP_148761417.1 HigA family addiction module antidote protein -
BMF77_RS05990 1308413..1308691 - 279 WP_148761419.1 type II toxin-antitoxin system RelE/ParE family toxin -
BMF77_RS05995 1308966..1309178 - 213 WP_148761421.1 type II toxin-antitoxin system HicB family antitoxin -
BMF77_RS06005 1309238..1309453 + 216 Protein_1182 type II toxin-antitoxin system Phd/YefM family antitoxin -
BMF77_RS06010 1309589..1309888 + 300 WP_148761425.1 BrnT family toxin -
BMF77_RS06015 1309885..1310085 + 201 WP_148761427.1 hypothetical protein -
BMF77_RS06020 1310308..1310766 + 459 WP_148761429.1 DUF1848 family protein -
BMF77_RS06025 1310690..1311601 - 912 WP_148761431.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-83)

Antitoxin

Uncharacterised protein family HicB

(52-102)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9643.00 Da        Isoelectric Point: 8.6585

>T137028 WP_148761411.1 NZ_CP043056:c1306871-1306611 [Dolichospermum sp. UHCC 0315A]
MDLNNKQRKTLELIFTNPVPANIIWQDIESLFIALGAYISQGSGSRVGVKLNDVKGHFHEPHPHKETDKGTVKSVREFLT
KAGFEP

Download         Length: 261 bp

>T137028 NZ_CP043056:c1306871-1306611 [Dolichospermum sp. UHCC 0315A]
ATGGATCTCAACAATAAACAAAGAAAAACTTTAGAATTAATTTTTACAAATCCTGTACCAGCAAATATTATTTGGCAAGA
TATTGAAAGTCTATTTATAGCTTTAGGTGCTTATATTAGTCAAGGTAGCGGTTCAAGAGTAGGAGTTAAATTAAATGATG
TTAAAGGTCATTTTCATGAACCACATCCCCATAAAGAAACAGATAAAGGAACTGTTAAATCTGTACGTGAATTTTTGACA
AAAGCAGGATTTGAACCATAA

Antitoxin


Download         Length: 113 a.a.        Molecular weight: 12543.41 Da        Isoelectric Point: 5.7723

>AT137028 WP_148761409.1 NZ_CP043056:c1306517-1306179 [Dolichospermum sp. UHCC 0315A]
MLTYKGYTASIEVDVEAGILFGRVLDINDVVTFKAKTVEEARQEFETSIDGYLAFCKELGEEPDKPFSGKLPFRTTPEHH
RKIFIAAKKAGKSINAWMDEMLINAAEKSVKA

Download         Length: 339 bp

>AT137028 NZ_CP056421:c3109379-3109077 [Citrobacter sp. RHBSTW-00524]
ATGGGCAGAACGCTGGAACAGCTTATTGCGGATGAAAAACCTGAAGTCGTGGCCGAAGCTCAGGCGATGGCGACGGACAT
CCTGCTCAACATTCACCTTGCCGAACTGCGCGAGAAAGTGCAGAGAACGCAGGTCGAAATGGCGAAGGCGCTGGGGATCA
GGCAACCTACCGTTGCAGGAATGGAAAAACCGGGGCGCGACCTGAAGCTTTCCACGCTGAAACGCTACGTTGAAGCGACC
GGCGGCAAGCTACGCCTTGATATTGAACTGCCGGATGGTTCTCACTACGGATTTGTACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References