Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 1276690..1277096 Replicon chromosome
Accession NZ_CP043056
Organism Dolichospermum sp. UHCC 0315A

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BMF77_RS05825 Protein ID WP_148761365.1
Coordinates 1276690..1276872 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BMF77_RS05830 Protein ID WP_015078601.1
Coordinates 1276869..1277096 (+) Length 76 a.a.

Genomic Context

BMF77_RS05790BMF77_RS05795BMF77_RS05825BMF77_RS05830BMF77_RS05845BMF77_RS05850BMF77_RS05855BMF77_RS05800BMF77_RS05805BMF77_RS05810BMF77_RS05820BMF77_RS05835BMF77_RS05840
Location: 1272095..1272697 (603 bp)
Type: Others
Protein ID: WP_148761353.1
Location: 1272755..1273570 (816 bp)
Type: Others
Protein ID: WP_148761355.1
Location: 1276690..1276872 (183 bp)
Type: Toxin
Protein ID: WP_148761365.1
Location: 1276869..1277096 (228 bp)
Type: Antitoxin
Protein ID: WP_015078601.1
Location: 1277875..1278495 (621 bp)
Type: Others
Protein ID: WP_148761371.1
Location: 1278533..1278967 (435 bp)
Type: Others
Protein ID: WP_015078603.1
Location: 1279128..1281809 (2682 bp)
Type: Others
Protein ID: WP_148761373.1
Location: 1273658..1274029 (372 bp)
Type: Others
Protein ID: WP_148761357.1
Location: 1274026..1274256 (231 bp)
Type: Others
Protein ID: WP_148761359.1
Location: 1274291..1274497 (207 bp)
Type: Others
Protein ID: WP_148761361.1
Location: 1275204..1276433 (1230 bp)
Type: Others
Protein ID: WP_148761363.1
Location: 1277159..1277551 (393 bp)
Type: Others
Protein ID: WP_148761368.1
Location: 1277552..1277800 (249 bp)
Type: Others
Protein ID: WP_148761369.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BMF77_RS057901272095..1272697+603WP_148761353.1cell division protein SepF-
BMF77_RS057951272755..1273570+816WP_148761355.1pyrroline-5-carboxylate reductase-
BMF77_RS058001273658..1274029-372WP_148761357.1DUF5615 family PIN-like protein-
BMF77_RS058051274026..1274256-231WP_148761359.1DUF433 domain-containing protein-
BMF77_RS058101274291..1274497-207WP_148761361.1DUF2281 domain-containing protein-
BMF77_RS058201275204..1276433-1230WP_148761363.1GTPase domain-containing protein-
BMF77_RS058251276690..1276872+183WP_148761365.1type II toxin-antitoxin system HicA family toxinToxin
BMF77_RS058301276869..1277096+228WP_015078601.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
BMF77_RS058351277159..1277551-393WP_148761368.1type II toxin-antitoxin system VapC family toxin-
BMF77_RS058401277552..1277800-249WP_148761369.1DUF2281 domain-containing protein-
BMF77_RS058451277875..1278495+621WP_148761371.1type I restriction enzyme HsdR N-terminal domain-containing protein-
BMF77_RS058501278533..1278967+435WP_015078603.1DUF29 domain-containing protein-
BMF77_RS058551279128..1281809+2682WP_148761373.1RNA helicase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(11-66)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6710.89 Da        Isoelectric Point: 10.6223

>T137027 WP_148761365.1 NZ_CP043056:1276690-1276872 [Dolichospermum sp. UHCC 0315A]
MKVKEVLKILEADGWYIDRTRGSHRILKHQSKSGIVVVPGKPSDDIPVGTLSSIWKQAKL

Download         Length: 183 bp

>T137027 NZ_CP043056:1276690-1276872 [Dolichospermum sp. UHCC 0315A]
ATGAAGGTTAAAGAAGTTCTCAAAATCCTGGAAGCAGATGGTTGGTATATAGATCGCACCAGAGGTAGTCATCGTATCCT
CAAACATCAAAGCAAATCAGGTATCGTAGTTGTACCTGGAAAACCAAGTGATGATATTCCAGTAGGTACACTCTCATCAA
TTTGGAAGCAAGCAAAATTATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8268.41 Da        Isoelectric Point: 3.8954

>AT137027 WP_015078601.1 NZ_CP043056:1276869-1277096 [Dolichospermum sp. UHCC 0315A]
MNEKMIEYTVIYERGQTNWGAYVPDLPGCVSIGDTLAEVQENIKEAIALYLEVLKEDGQPIPEPSTEVGKVAVTI

Download         Length: 228 bp

>AT137027 NZ_CP043056:1276869-1277096 [Dolichospermum sp. UHCC 0315A]
ATGAACGAAAAAATGATTGAGTACACAGTCATCTACGAACGTGGACAGACAAACTGGGGTGCTTATGTTCCCGACTTACC
TGGTTGTGTCAGTATTGGCGATACTTTAGCAGAAGTACAGGAAAATATTAAAGAAGCGATCGCATTATACCTAGAAGTAT
TGAAAGAAGATGGACAACCCATACCCGAACCATCAACAGAAGTTGGTAAAGTTGCAGTGACAATATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References