Detailed information of TA system TA137027

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-UPF0150
• Location: 1276690..1277096
• Replicon: chromosome
• Accession: NZ_CP043056
• Organism: Dolichospermum sp. UHCC 0315A

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: BMF77_RS05825
• Protein ID: WP_148761365.1
• Coordinates: 1276690..1276872 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: BMF77_RS05830
• Protein ID: WP_015078601.1
• Coordinates: 1276869..1277096 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BMF77_RS05790	1272095..1272697	+	603	WP_148761353.1	cell division protein SepF	-
BMF77_RS05795	1272755..1273570	+	816	WP_148761355.1	pyrroline-5-carboxylate reductase	-
BMF77_RS05800	1273658..1274029	-	372	WP_148761357.1	DUF5615 family PIN-like protein	-
BMF77_RS05805	1274026..1274256	-	231	WP_148761359.1	DUF433 domain-containing protein	-
BMF77_RS05810	1274291..1274497	-	207	WP_148761361.1	DUF2281 domain-containing protein	-
BMF77_RS05820	1275204..1276433	-	1230	WP_148761363.1	GTPase domain-containing protein	-
BMF77_RS05825	1276690..1276872	+	183	WP_148761365.1	type II toxin-antitoxin system HicA family toxin	Toxin
BMF77_RS05830	1276869..1277096	+	228	WP_015078601.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BMF77_RS05835	1277159..1277551	-	393	WP_148761368.1	type II toxin-antitoxin system VapC family toxin	-
BMF77_RS05840	1277552..1277800	-	249	WP_148761369.1	DUF2281 domain-containing protein	-
BMF77_RS05845	1277875..1278495	+	621	WP_148761371.1	type I restriction enzyme HsdR N-terminal domain-containing protein	-
BMF77_RS05850	1278533..1278967	+	435	WP_015078603.1	DUF29 domain-containing protein	-
BMF77_RS05855	1279128..1281809	+	2682	WP_148761373.1	RNA helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (11-66)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6710.89 Da
• Isoelectric Point: 10.6223

>T137027 WP_148761365.1 NZ_CP043056:1276690-1276872 [Dolichospermum sp. UHCC 0315A]
MKVKEVLKILEADGWYIDRTRGSHRILKHQSKSGIVVVPGKPSDDIPVGTLSSIWKQAKL

Nucleotide

• Length: 183 bp

>T137027 NZ_CP043056:1276690-1276872 [Dolichospermum sp. UHCC 0315A]
ATGAAGGTTAAAGAAGTTCTCAAAATCCTGGAAGCAGATGGTTGGTATATAGATCGCACCAGAGGTAGTCATCGTATCCT
CAAACATCAAAGCAAATCAGGTATCGTAGTTGTACCTGGAAAACCAAGTGATGATATTCCAGTAGGTACACTCTCATCAA
TTTGGAAGCAAGCAAAATTATGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8268.41 Da
• Isoelectric Point: 3.8954

>AT137027 WP_015078601.1 NZ_CP043056:1276869-1277096 [Dolichospermum sp. UHCC 0315A]
MNEKMIEYTVIYERGQTNWGAYVPDLPGCVSIGDTLAEVQENIKEAIALYLEVLKEDGQPIPEPSTEVGKVAVTI

Nucleotide

• Length: 228 bp

>AT137027 NZ_CP043056:1276869-1277096 [Dolichospermum sp. UHCC 0315A]
ATGAACGAAAAAATGATTGAGTACACAGTCATCTACGAACGTGGACAGACAAACTGGGGTGCTTATGTTCCCGACTTACC
TGGTTGTGTCAGTATTGGCGATACTTTAGCAGAAGTACAGGAAAATATTAAAGAAGCGATCGCATTATACCTAGAAGTAT
TGAAAGAAGATGGACAACCCATACCCGAACCATCAACAGAAGTTGGTAAAGTTGCAGTGACAATATAA