Detailed information of TA system TA137025

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/DUF433(antitoxin)
• Location: 122961..123532
• Replicon: chromosome
• Accession: NZ_CP043056
• Organism: Dolichospermum sp. UHCC 0315A

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BMF77_RS00615
• Protein ID: WP_148759831.1
• Coordinates: 122961..123302 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BMF77_RS00620
• Protein ID: WP_148759833.1
• Coordinates: 123299..123532 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BMF77_RS00580	118278..118496	-	219	WP_210422273.1	hypothetical protein	-
BMF77_RS00585	118564..118731	-	168	WP_148759825.1	type II toxin-antitoxin system PemK/MazF family toxin	-
BMF77_RS00590	118721..118951	-	231	WP_137908734.1	hypothetical protein	-
BMF77_RS00595	119031..119405	-	375	WP_210422274.1	putative toxin-antitoxin system toxin component, PIN family	-
BMF77_RS00600	119395..119643	-	249	WP_053541040.1	hypothetical protein	-
BMF77_RS00605	119821..120738	+	918	WP_148759827.1	hypothetical protein	-
BMF77_RS00610	120938..122620	+	1683	WP_148759829.1	hypothetical protein	-
BMF77_RS00615	122961..123302	-	342	WP_148759831.1	DUF5615 family PIN-like protein	Toxin
BMF77_RS00620	123299..123532	-	234	WP_148759833.1	DUF433 domain-containing protein	Antitoxin
BMF77_RS00625	123553..123753	+	201	Protein_121	hypothetical protein	-
BMF77_RS00630	123880..125616	-	1737	WP_148759835.1	GTPase HflX	-
BMF77_RS00635	125666..125888	+	223	Protein_123	hypothetical protein	-
BMF77_RS00640	126073..126435	+	363	WP_015078221.1	50S ribosomal protein L19	-
BMF77_RS00650	127226..127447	+	222	WP_015078220.1	preprotein translocase subunit SecE	-
BMF77_RS00655	127447..128079	+	633	WP_015078219.1	transcription termination/antitermination protein NusG	-
BMF77_RS00660	128086..128511	+	426	WP_015078218.1	50S ribosomal protein L11	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Domain of unknown function DUF5615 (1-78)

Antitoxin

• Protein of unknown function DUF433 (11-66)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12737.92 Da
• Isoelectric Point: 4.3063

>T137025 WP_148759831.1 NZ_CP043056:c123302-122961 [Dolichospermum sp. UHCC 0315A]
MKIWIDAQLPATLAIWVTDTFAIEAFSLRDIGLRDAKDIEIFEAAKIANVIIMTKDSDFVDLVCRLGIPPQILWLTCGNV
TNRNLRQLLIITLPDALEQLQQGEMIVEISNSR

Nucleotide

• Length: 342 bp

>T137025 NZ_CP043056:c123302-122961 [Dolichospermum sp. UHCC 0315A]
ATGAAAATTTGGATTGATGCACAGTTACCAGCAACATTGGCAATTTGGGTAACAGATACTTTTGCTATAGAAGCATTTTC
ATTAAGAGATATTGGGTTACGTGATGCTAAAGATATAGAAATTTTTGAAGCTGCAAAAATCGCTAATGTCATCATCATGA
CGAAAGACAGTGATTTTGTTGATTTGGTTTGTCGGTTAGGAATACCTCCTCAAATCCTTTGGTTAACTTGTGGAAATGTG
ACGAATCGCAATCTGCGTCAACTTCTGATCATTACTTTACCTGATGCTTTGGAACAATTACAGCAAGGAGAAATGATTGT
GGAAATCAGCAATAGTCGGTAA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8662.01 Da
• Isoelectric Point: 4.3466

>AT137025 WP_148759833.1 NZ_CP043056:c123532-123299 [Dolichospermum sp. UHCC 0315A]
INSMNELLNRITQIPGQCGGRPCIRGMRIRVSDILEMLAENVSVSEILEDFPDLEPEDIQACLVFAARRTDFVRLTA

Nucleotide

• Length: 234 bp

>AT137025 NZ_CP043056:c123532-123299 [Dolichospermum sp. UHCC 0315A]
ATTAACTCAATGAACGAATTATTAAATCGGATTACGCAAATTCCTGGTCAATGTGGGGGTCGTCCTTGCATTCGCGGAAT
GAGAATTAGAGTTAGCGACATTTTAGAAATGTTAGCCGAAAATGTCAGCGTTAGCGAAATTTTAGAAGACTTTCCCGATT
TAGAACCAGAAGATATTCAAGCTTGTCTTGTGTTTGCTGCACGACGGACTGATTTTGTCCGGTTAACAGCATGA