Detailed information of TA system TA137019

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2674632..2675311
• Replicon: chromosome
• Accession: NZ_CP043052
• Organism: Acinetobacter pittii strain AP43

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: FXO17_RS12845
• Protein ID: WP_000838146.1
• Coordinates: 2675129..2675311 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: FXO17_RS12840
• Protein ID: WP_000966688.1
• Coordinates: 2674632..2675036 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXO17_RS12830	2673588..2673851	-	264	WP_001275792.1	hypothetical protein	-
FXO17_RS12835	2673853..2674533	-	681	WP_000721572.1	hypothetical protein	-
FXO17_RS12840	2674632..2675036	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FXO17_RS12845	2675129..2675311	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
FXO17_RS12850	2675637..2676152	-	516	WP_025464105.1	hypothetical protein	-
FXO17_RS12855	2676223..2677140	-	918	WP_002121543.1	hypothetical protein	-
FXO17_RS12860	2677193..2678521	-	1329	WP_023187966.1	hypothetical protein	-
FXO17_RS12865	2678521..2678874	-	354	WP_002121621.1	hypothetical protein	-
FXO17_RS12870	2678943..2679341	-	399	WP_002121567.1	hypothetical protein	-
FXO17_RS12875	2679343..2679711	-	369	WP_000539743.1	hypothetical protein	-
FXO17_RS12880	2679683..2680087	-	405	WP_002121581.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2640459..2695938	55479

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T137019 WP_000838146.1 NZ_CP043052:c2675311-2675129 [Acinetobacter pittii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T137019 NZ_CP043052:c2675311-2675129 [Acinetobacter pittii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT137019 WP_000966688.1 NZ_CP043052:c2675036-2674632 [Acinetobacter pittii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT137019 NZ_CP043052:c2675036-2674632 [Acinetobacter pittii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6