Detailed information of TA system TA137018

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 492868..493509
• Replicon: chromosome
• Accession: NZ_CP043052
• Organism: Acinetobacter pittii strain AP43

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: FXO17_RS02395
• Protein ID: WP_016802636.1
• Coordinates: 493120..493509 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: F0KQ03
• Locus tag: FXO17_RS02390
• Protein ID: WP_014207740.1
• Coordinates: 492868..493113 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXO17_RS02370	488369..489376	+	1008	WP_002116730.1	DNA-directed RNA polymerase subunit alpha	-
FXO17_RS02375	489395..489772	+	378	WP_002049717.1	50S ribosomal protein L17	-
FXO17_RS02380	489954..491444	+	1491	WP_148728109.1	NAD(P)/FAD-dependent oxidoreductase	-
FXO17_RS02385	491495..492667	-	1173	WP_002116790.1	acyl-CoA dehydrogenase family protein	-
FXO17_RS02390	492868..493113	+	246	WP_014207740.1	succinate dehydrogenase assembly factor 2	Antitoxin
FXO17_RS02395	493120..493509	+	390	WP_016802636.1	hypothetical protein	Toxin
FXO17_RS02400	494280..495368	+	1089	WP_002116869.1	hypothetical protein	-
FXO17_RS02405	495453..496028	+	576	WP_005078319.1	rhombosortase	-
FXO17_RS02410	496208..498418	+	2211	WP_002116854.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (6-78)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15475.66 Da
• Isoelectric Point: 7.9230

>T137018 WP_016802636.1 NZ_CP043052:493120-493509 [Acinetobacter pittii]
MIKELNFELKYSLVSVIFQLFVGLGLAILLYQLLTPIWWLCAVILLFIGFIFFLKQAQISQIEYLDQKLWSVAYFSKKEI
YRAEITKIIDYQLFVVIYLEETPTIIAIVWFDQLPIQQWKRLKVLEKLY

Nucleotide

• Length: 390 bp

>T137018 NZ_CP043052:493120-493509 [Acinetobacter pittii]
TTGATAAAAGAATTAAATTTTGAGCTGAAATATAGCCTTGTCTCGGTAATATTTCAGCTTTTTGTTGGTTTGGGTTTAGC
AATCCTGCTTTATCAATTATTAACACCGATATGGTGGCTATGTGCTGTCATTCTTCTATTTATTGGTTTTATTTTCTTTC
TAAAGCAAGCCCAAATATCTCAAATTGAATATTTAGATCAAAAATTATGGTCGGTTGCATATTTTTCGAAAAAAGAAATT
TACCGCGCGGAAATTACTAAAATAATTGATTATCAGTTATTTGTAGTTATTTATCTTGAAGAAACTCCTACGATCATAGC
TATTGTTTGGTTCGATCAGCTTCCTATTCAGCAGTGGAAAAGATTAAAAGTTTTAGAAAAGCTCTATTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9833.26 Da
• Isoelectric Point: 4.7037

>AT137018 WP_014207740.1 NZ_CP043052:492868-493113 [Acinetobacter pittii]
MTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLKQYVH
G

Nucleotide

• Length: 246 bp

>AT137018 NZ_CP043052:492868-493113 [Acinetobacter pittii]
ATGACCTTGGAAGAACGTAAAGTAATTTATCGAGCACGCCGCGGCTTAAAAGAAATTGACGTCTATTTTGACCCGTATGT
AAAAAACTATTATTTAAAAGCTGATCCAGCAGAAAAAGCATTATTTGCAGAGTTAGTCGATCAAGAAGATCCGGATTTAT
TAGATTGGTTCATGGAAGTTTCTGAACCTCCACGTACTGAGTTACGTGAATTTATTTATAAACTAAAACAGTATGTGCAT
GGCTAA

Structures

Antitoxin

• AlphaFold DB: F0KQ03