Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3388730..3389349 Replicon chromosome
Accession NZ_CP043047
Organism Klebsiella pneumoniae strain KLP268

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FXN60_RS16595 Protein ID WP_002892050.1
Coordinates 3388730..3388948 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag FXN60_RS16600 Protein ID WP_002892066.1
Coordinates 3388975..3389349 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN60_RS16565 3384777..3385040 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
FXN60_RS16570 3385040..3385180 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
FXN60_RS16575 3385177..3385875 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
FXN60_RS16580 3385976..3387427 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
FXN60_RS16585 3387402..3387872 - 471 WP_002892026.1 YlaC family protein -
FXN60_RS29995 3387893..3388033 + 141 WP_004147370.1 hypothetical protein -
FXN60_RS16590 3388005..3388571 - 567 WP_002892030.1 maltose O-acetyltransferase -
FXN60_RS16595 3388730..3388948 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
FXN60_RS16600 3388975..3389349 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
FXN60_RS16605 3389835..3392981 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
FXN60_RS16610 3393004..3394197 - 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T137006 WP_002892050.1 NZ_CP043047:c3388948-3388730 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T137006 NZ_CP043047:c3388948-3388730 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT137006 WP_002892066.1 NZ_CP043047:c3389349-3388975 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT137006 NZ_CP056399:c4385227-4384910 [Citrobacter sp. RHBSTW-00570]
ATGAGCAACACTACATGGGGCCTGCAGCGGGATATCACTCCGAGCCTGGGAGCACGTCTGGTGCAGGAGGGCAATCGGCT
GCACTATCTGGCTGACCGGGCTAGTATCACCGGTAAGTTTAGTGACGAAGAATGTCTTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGTCATGCCCACTGCGTCACCCTGTACCAC
AACAGTTTCATCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTACACATCGCCATTTACCCCGCTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References