137004

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2674050..2674566 Replicon chromosome
Accession NZ_CP043047
Organism Klebsiella pneumoniae strain KLP268

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag FXN60_RS13160 Protein ID WP_002886902.1
Coordinates 2674282..2674566 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag FXN60_RS13155 Protein ID WP_002886901.1
Coordinates 2674050..2674292 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN60_RS13140 2670079..2670819 + 741 WP_002886899.1 KDGP aldolase family protein -
FXN60_RS13145 2670885..2672039 + 1155 WP_002886900.1 lactonase family protein -
FXN60_RS13150 2672062..2673972 + 1911 WP_004152270.1 BglG family transcription antiterminator -
FXN60_RS13155 2674050..2674292 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FXN60_RS13160 2674282..2674566 + 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FXN60_RS13165 2674570..2675034 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FXN60_RS13170 2675275..2677413 - 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
FXN60_RS13175 2677770..2678513 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
FXN60_RS29930 2678516..2678689 - 174 WP_002886906.1 hypothetical protein -
FXN60_RS13180 2678774..2679082 + 309 WP_002886907.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T137004 WP_002886902.1 NZ_CP043047:2674282-2674566 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T137004 NZ_CP043047:2674282-2674566 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT137004 WP_002886901.1 NZ_CP043047:2674050-2674292 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT137004 NZ_CP056399:3008770-3008913 [Citrobacter sp. RHBSTW-00570]
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References