136998

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1233823..1234480 Replicon chromosome
Accession NZ_CP043047
Organism Klebsiella pneumoniae strain KLP268

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag FXN60_RS05970 Protein ID WP_002916310.1
Coordinates 1233823..1234233 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag FXN60_RS05975 Protein ID WP_002916312.1
Coordinates 1234214..1234480 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN60_RS05950 1229823..1231556 - 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -
FXN60_RS05955 1231562..1232275 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FXN60_RS05960 1232298..1233194 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
FXN60_RS05965 1233295..1233816 + 522 WP_002916308.1 flavodoxin FldB -
FXN60_RS05970 1233823..1234233 - 411 WP_002916310.1 protein YgfX Toxin
FXN60_RS05975 1234214..1234480 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
FXN60_RS05980 1234726..1235709 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
FXN60_RS05985 1235860..1236519 - 660 WP_002916317.1 hemolysin III family protein -
FXN60_RS05990 1236683..1236994 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
FXN60_RS05995 1237044..1237772 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
FXN60_RS06000 1237891..1239324 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T136998 WP_002916310.1 NZ_CP043047:c1234233-1233823 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T136998 NZ_CP043047:c1234233-1233823 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT136998 WP_002916312.1 NZ_CP043047:c1234480-1234214 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT136998 NZ_CP043047:c1234480-1234214 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References