Detailed information of TA system TA136997

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 4523593..4524150
• Replicon: chromosome
• Accession: NZ_CP043046
• Organism: Pigmentiphaga aceris strain Mada1488

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FXN63_RS19625
• Protein ID: WP_148819596.1
• Coordinates: 4523593..4523748 (+)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FXN63_RS19630
• Protein ID: WP_148819598.1
• Coordinates: 4523761..4524150 (+)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXN63_RS19610	4520105..4521793	+	1689	WP_148816844.1	urocanate hydratase	-
FXN63_RS19615	4521796..4522389	+	594	WP_148816845.1	HutD family protein	-
FXN63_RS19620	4522398..4523615	+	1218	WP_148816846.1	imidazolonepropionase	-
FXN63_RS19625	4523593..4523748	+	156	WP_148819596.1	type II toxin-antitoxin system HicA family toxin	Toxin
FXN63_RS19630	4523761..4524150	+	390	WP_148819598.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FXN63_RS19635	4524176..4526227	-	2052	WP_148816847.1	sigma-54-dependent Fis family transcriptional regulator	-
FXN63_RS19640	4526549..4527826	+	1278	WP_148816848.1	PQQ-dependent sugar dehydrogenase	-
FXN63_RS19645	4527836..4528156	+	321	WP_148816849.1	cytochrome c	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (24-50)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-122)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5506.64 Da
• Isoelectric Point: 10.7860

>T136997 WP_148819596.1 NZ_CP043046:4523593-4523748 [Pigmentiphaga aceris]
MRTWQALDALSHCAFVVLLSITLKGTVPIPHPKKDLPIGTVRSALKQAGLL

Nucleotide

• Length: 156 bp

>T136997 NZ_CP043046:4523593-4523748 [Pigmentiphaga aceris]
CTGCGTACTTGGCAGGCGCTTGATGCGTTAAGTCACTGTGCCTTTGTTGTACTGCTGAGCATTACACTCAAGGGCACAGT
GCCGATCCCGCATCCGAAAAAAGACTTGCCGATAGGTACGGTACGAAGCGCCCTCAAGCAAGCCGGTCTACTCTGA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 14241.11 Da
• Isoelectric Point: 4.5829

>AT136997 WP_148819598.1 NZ_CP043046:4523761-4524150 [Pigmentiphaga aceris]
VLYPIYVHKEAESAYGVIFPDFPGCFSAADEAHDIARMAQEAVEAHFNDDDAPIPLPSAPDAWMNDPDYQGGFWMMVDID
LSKVKAKAVRLNISLPENLVQRIDAAAKARHLSRSAFLALAATREMADH

Nucleotide

• Length: 390 bp

>AT136997 NZ_CP043046:4523761-4524150 [Pigmentiphaga aceris]
GTGCTCTACCCAATCTATGTTCACAAGGAAGCGGAAAGCGCCTACGGCGTGATCTTTCCGGATTTTCCTGGCTGCTTTTC
TGCCGCCGACGAGGCCCATGACATTGCACGCATGGCGCAGGAGGCCGTTGAGGCGCACTTCAATGATGACGATGCGCCGA
TCCCGTTGCCTAGCGCACCGGACGCCTGGATGAATGATCCGGACTATCAGGGTGGTTTCTGGATGATGGTCGACATCGAC
CTGTCGAAGGTGAAAGCCAAAGCGGTTCGCCTGAATATCAGCCTGCCTGAAAACCTGGTCCAACGAATCGATGCAGCGGC
GAAAGCGCGCCATCTGAGCCGGTCGGCCTTTCTTGCGCTGGCGGCTACACGCGAAATGGCGGATCACTGA