Detailed information of TA system TA136994

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 23905..24587
• Replicon: plasmid unnamed1
• Accession: NZ_CP043044
• Organism: Gluconobacter thailandicus strain HD924

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FXF46_RS15705
• Protein ID: WP_148621247.1
• Coordinates: 24174..24587 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A149QZE5
• Locus tag: FXF46_RS15700
• Protein ID: WP_062493883.1
• Coordinates: 23905..24177 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXF46_RS15675	19314..20678	+	1365	WP_148621244.1	replicator initiator RepC	-
FXF46_RS15680	21181..22041	+	861	WP_148621366.1	O-antigen ligase family protein	-
FXF46_RS15690	22296..23123	+	828	WP_148621246.1	hypothetical protein	-
FXF46_RS15695	23266..23634	+	369	WP_148621367.1	hypothetical protein	-
FXF46_RS15700	23905..24177	+	273	WP_062493883.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FXF46_RS15705	24174..24587	+	414	WP_148621247.1	type II toxin-antitoxin system VapC family toxin	Toxin
FXF46_RS15710	25145..28285	-	3141	WP_148621248.1	error-prone DNA polymerase	-
FXF46_RS15715	28289..28522	-	234	WP_099213657.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..173039	173039

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (16-53)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 14817.10 Da
• Isoelectric Point: 4.8837

>T136994 WP_148621247.1 NZ_CP043044:24174-24587 [Gluconobacter thailandicus]
VSAYLLDTNIISDLVRNPSGSAAKRIEQLNPGDLCTSIIVASELRYGCAKKGSPKLLARVESVLAFVPILPLDIPVDGEY
GGIRVELEAAGQTIGMNDLLIAAHAYTLKAILVTNNVREFSRVRGLQVENWLEEAVQ

Nucleotide

• Length: 414 bp

>T136994 NZ_CP043044:24174-24587 [Gluconobacter thailandicus]
GTGAGCGCCTATCTTCTTGATACAAATATTATCAGCGATCTTGTCCGCAACCCCTCTGGGTCGGCAGCAAAGCGCATCGA
ACAGCTCAATCCGGGCGACCTGTGTACCAGCATCATTGTAGCCTCGGAGCTGCGATATGGATGTGCAAAAAAGGGCTCTC
CGAAACTCCTGGCCCGCGTTGAAAGCGTGCTGGCTTTTGTACCGATATTACCACTCGATATTCCAGTCGATGGCGAATAC
GGAGGCATTCGGGTGGAACTCGAAGCAGCAGGGCAAACAATCGGTATGAATGATTTACTGATCGCGGCCCACGCATACAC
GCTCAAAGCTATCTTGGTGACGAACAATGTCCGTGAGTTCAGCCGCGTCAGAGGGCTGCAGGTCGAAAATTGGTTAGAGG
AAGCGGTGCAGTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10186.71 Da
• Isoelectric Point: 4.4569

>AT136994 WP_062493883.1 NZ_CP043044:23905-24177 [Gluconobacter thailandicus]
MPVPEIPPRPREVKLFRNNRSQAVRIPVEFELPGDRALIRRDGERLVIEPVKAPSSLSELLAAWREEPPLAPDDDFPEVL
DVAAKPEDIL

Nucleotide

• Length: 273 bp

>AT136994 NZ_CP043044:23905-24177 [Gluconobacter thailandicus]
ATGCCGGTCCCAGAAATTCCCCCGCGCCCACGGGAAGTAAAACTCTTTCGGAATAATCGCAGCCAGGCAGTCCGTATTCC
TGTCGAATTTGAACTGCCGGGAGACCGCGCGCTTATCCGACGCGATGGGGAAAGACTGGTGATTGAGCCCGTCAAAGCTC
CATCTTCGCTGAGCGAACTCCTCGCAGCATGGCGAGAAGAGCCACCCCTGGCTCCGGACGATGACTTCCCCGAAGTTCTT
GACGTAGCTGCCAAGCCAGAAGATATCCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A149QZE5