Detailed information of TA system TA136993

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3132762..3133359
• Replicon: chromosome
• Accession: NZ_CP043043
• Organism: Gluconobacter thailandicus strain HD924

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FXF46_RS14365
• Protein ID: WP_148620958.1
• Coordinates: 3132762..3132944 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FXF46_RS14370
• Protein ID: WP_148620959.1
• Coordinates: 3132964..3133359 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXF46_RS14335	3128527..3129837	-	1311	WP_148620953.1	phage terminase large subunit	-
FXF46_RS14340	3129840..3130352	-	513	WP_148620954.1	terminase small subunit	-
FXF46_RS14345	3130376..3130573	-	198	WP_148620955.1	hypothetical protein	-
FXF46_RS14350	3130578..3131411	-	834	WP_148620956.1	tyrosine-type recombinase/integrase	-
FXF46_RS14355	3131599..3131919	-	321	WP_148620957.1	hypothetical protein	-
FXF46_RS14360	3131978..3132637	-	660	WP_208797024.1	hypothetical protein	-
FXF46_RS14365	3132762..3132944	+	183	WP_148620958.1	type II toxin-antitoxin system HicA family toxin	Toxin
FXF46_RS14370	3132964..3133359	+	396	WP_148620959.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FXF46_RS17130	3133356..3133529	+	174	WP_167626895.1	hypothetical protein	-
FXF46_RS14375	3133740..3134153	-	414	WP_148620960.1	hypothetical protein	-
FXF46_RS14380	3134150..3134362	-	213	WP_148620961.1	hypothetical protein	-
FXF46_RS17135	3134508..3134663	-	156	WP_167626896.1	hypothetical protein	-
FXF46_RS14385	3134660..3136003	-	1344	WP_148620962.1	DUF4942 domain-containing protein	-
FXF46_RS14390	3136008..3136382	-	375	WP_148620963.1	hypothetical protein	-
FXF46_RS14395	3136397..3137902	-	1506	WP_148620964.1	AAA family ATPase	-
FXF46_RS14400	3137895..3138086	-	192	WP_148620965.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3088317..3156331	68014

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6773.90 Da
• Isoelectric Point: 10.9883

>T136993 WP_148620958.1 NZ_CP043043:3132762-3132944 [Gluconobacter thailandicus]
MNSAELIRELKKAGWEEVRCRGSHHIFRHKDHGHSITVPHPKKDLGKGLVAAIRKQAGLK

Nucleotide

• Length: 183 bp

>T136993 NZ_CP043043:3132762-3132944 [Gluconobacter thailandicus]
ATGAACAGCGCCGAACTAATCCGAGAGCTGAAAAAAGCAGGATGGGAAGAAGTCAGATGCCGGGGATCACATCACATATT
CCGCCACAAGGACCATGGACACTCGATCACAGTCCCCCACCCTAAAAAAGACCTCGGAAAAGGTTTGGTGGCAGCAATCA
GAAAACAGGCCGGGTTGAAATAA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14397.27 Da
• Isoelectric Point: 4.1316

>AT136993 WP_148620959.1 NZ_CP043043:3132964-3133359 [Gluconobacter thailandicus]
MRYPIVIERASDTQAFGVIVPDLPGCFSAGDTFNEAIDNAQEAMALWIEDALDNCNTVPAPSDLDTLRATGQWSGSEWIW
GFVDIDPALLDEKFERVNITLPRRVIARLDRVAKEAGESRSSMIAKLALSA

Nucleotide

• Length: 396 bp

>AT136993 NZ_CP043043:3132964-3133359 [Gluconobacter thailandicus]
ATGAGATACCCAATCGTGATTGAGCGCGCATCAGATACCCAAGCATTCGGTGTGATCGTGCCTGATCTTCCAGGCTGCTT
CTCCGCTGGCGATACGTTCAACGAAGCAATCGACAACGCTCAGGAAGCAATGGCGCTATGGATCGAAGATGCGCTTGATA
ACTGCAACACCGTTCCGGCACCGAGTGATCTCGATACGCTCCGAGCCACGGGTCAGTGGTCGGGCTCTGAATGGATCTGG
GGGTTTGTGGATATTGATCCGGCGCTGCTGGATGAAAAGTTCGAGCGCGTAAATATCACGCTACCTCGGCGCGTTATTGC
TCGCCTTGACCGCGTAGCTAAAGAGGCGGGCGAAAGTCGTTCCAGCATGATTGCAAAACTGGCACTCAGCGCATGA