Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 654572..655173 Replicon chromosome
Accession NZ_CP043043
Organism Gluconobacter thailandicus strain HD924

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FXF46_RS03180 Protein ID WP_148619578.1
Coordinates 654772..655173 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FXF46_RS03175 Protein ID WP_148619576.1
Coordinates 654572..654769 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXF46_RS03155 650236..651996 + 1761 WP_148619570.1 tyrosine-type recombinase/integrase -
FXF46_RS03160 651993..652544 + 552 WP_148619572.1 GNAT family N-acetyltransferase -
FXF46_RS03165 652714..653286 + 573 WP_148621120.1 AAA family ATPase -
FXF46_RS03170 653460..654224 - 765 WP_148619574.1 hypothetical protein -
FXF46_RS03175 654572..654769 + 198 WP_148619576.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FXF46_RS03180 654772..655173 + 402 WP_148619578.1 PIN domain-containing protein Toxin
FXF46_RS03185 655266..656429 + 1164 WP_148619580.1 aspartyl protease family protein -
FXF46_RS03190 656694..657407 - 714 WP_148619582.1 DNA alkylation repair protein -
FXF46_RS03195 657756..658307 + 552 WP_186004332.1 GNAT family N-acetyltransferase -
FXF46_RS03200 658464..658982 + 519 WP_148619583.1 hypothetical protein -
FXF46_RS03205 659238..659819 - 582 WP_148619585.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-115)

Antitoxin

SpoVT-AbrB domain

(5-31)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15062.33 Da        Isoelectric Point: 4.4731

>T136992 WP_148619578.1 NZ_CP043043:654772-655173 [Gluconobacter thailandicus]
IPVLLDTNILLYACIEQDVEKMRIAEDILRHADCHISVQSLNEMTNTLRRKTKLSLDDIGELIADIRSLTTVHDLTTGIY
ARGWAIVRRYGLQTYDSMILACAIENGFETVLSEDMQDGLSIFDMTIIRNPFG

Download         Length: 402 bp

>T136992 NZ_CP043043:654772-655173 [Gluconobacter thailandicus]
ATACCCGTTCTTCTGGATACCAATATCCTGCTCTATGCGTGCATAGAGCAGGATGTGGAAAAGATGCGGATCGCTGAAGA
TATTCTCCGCCATGCGGATTGTCATATCTCTGTCCAATCTCTGAACGAGATGACGAATACGTTGCGTCGTAAAACAAAGC
TGTCTCTGGATGATATTGGCGAGCTGATTGCAGACATTAGAAGTCTGACAACCGTACATGACCTAACGACAGGTATTTAT
GCCAGGGGGTGGGCAATTGTACGCCGTTATGGCTTGCAGACCTATGACAGTATGATTTTGGCGTGTGCTATCGAAAACGG
CTTTGAAACGGTATTGTCAGAAGACATGCAGGATGGGCTGTCTATTTTCGATATGACGATTATTAGAAACCCGTTTGGAT
AG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7415.55 Da        Isoelectric Point: 10.9210

>AT136992 WP_148619576.1 NZ_CP043043:654572-654769 [Gluconobacter thailandicus]
MQVSKWGNSLAVRIPAHIVRQLGLQEGDNVEAVFSRLKSPEEALQSLKTIGRKLPKNFRFERPQD

Download         Length: 198 bp

>AT136992 NZ_CP056395:2466294-2466578 [Citrobacter freundii]
ATGAAAATGGCTAATCATCCCCGTCCGGGGGATATTATTCAGGAAGCGCTGGATGAGTTAAACGTCAGCCTGCGCGAATT
TGCCAGAGCAATGGAGATTGCCCCCTCAACCGCGAGCCGACTGTTAACGGGCAAGGCAGCATTAACCCCGGAAATGGCGA
TCAAACTTTCAGTGGTGATCGGCAGTTCGCCCGAAATGTGGTTGAATCTGCAGAATGCCTGGAGTCTGGCTGAAGCGCAA
AAAAGCGTGGATATCTCACGTCTGCGCAAACTGGTAGCACAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References