Detailed information of TA system TA136991

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 541442..542077
• Replicon: chromosome
• Accession: NZ_CP043043
• Organism: Gluconobacter thailandicus strain HD924

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FXF46_RS02630
• Protein ID: WP_148619479.1
• Coordinates: 541442..541852 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FXF46_RS02635
• Protein ID: WP_148619481.1
• Coordinates: 541853..542077 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXF46_RS02625	538582..541230	+	2649	WP_148619477.1	hypothetical protein	-
FXF46_RS02630	541442..541852	-	411	WP_148619479.1	tRNA(fMet)-specific endonuclease VapC	Toxin
FXF46_RS02635	541853..542077	-	225	WP_148619481.1	antitoxin	Antitoxin
FXF46_RS02645	542397..543267	+	871	Protein_499	integrase core domain-containing protein	-
FXF46_RS02650	543478..546054	-	2577	WP_148619482.1	TonB-dependent receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	542397..542834	437

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (9-55)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15423.67 Da
• Isoelectric Point: 7.2163

>T136991 WP_148619479.1 NZ_CP043043:c541852-541442 [Gluconobacter thailandicus]
MLRYLLDTNLCIRVLRDRPQGLRPRFNSCAEELCISDVVLYELLYGAERSSDPVRTRREVEHFAARLAVLPFDSEAAAHT
ADIRAALERNGRIIGPYDLMIAGHARSRGLIVVTGNLREFQRVEGLRTEDWLTGTV

Nucleotide

• Length: 411 bp

>T136991 NZ_CP043043:c541852-541442 [Gluconobacter thailandicus]
ATGCTGCGTTACCTACTGGATACGAACCTCTGTATCCGGGTGTTGCGGGATCGACCACAGGGGCTGCGTCCGAGATTCAA
CAGCTGTGCGGAGGAACTCTGCATCTCGGACGTGGTTCTGTATGAACTGCTTTATGGCGCGGAGCGCTCGTCTGATCCTG
TGCGCACCAGACGCGAGGTTGAGCACTTCGCGGCAAGGCTGGCAGTCCTGCCATTCGACAGTGAAGCGGCTGCCCATACA
GCGGATATTCGGGCTGCTCTTGAACGGAATGGCCGTATCATAGGTCCATATGATCTCATGATTGCCGGGCATGCCCGGAG
CAGGGGGCTGATTGTGGTGACCGGGAACCTTCGGGAATTCCAGCGGGTGGAGGGTCTTCGGACGGAGGATTGGCTGACTG
GCACGGTCTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8279.46 Da
• Isoelectric Point: 5.0181

>AT136991 WP_148619481.1 NZ_CP043043:c542077-541853 [Gluconobacter thailandicus]
MLTRTTLFLSNRSQAVRLPKMVAFGEQVREVVIVSEGSRRIIAPADAAWDDFFAAPGVELGERNQPAMQEREAF

Nucleotide

• Length: 225 bp

>AT136991 NZ_CP056395:c2426554-2426258 [Citrobacter freundii]
ATGGAGAAACTTATGCAAACCAGCGCTCGTAAGCCAACTCGCGATAAGCAAATTAATATCCGCGCTACTGATGAGGAACG
CGCAGTGATTGATTATGCCGCAAGTTTGGTTAATAAAAACCGCACTGACTTTATCATTGAGAAGGCCGTGCATGAGGCCC
AGAATATCATTCTGGATCAGCGTGTGTTCGTCCTGGACGATGCCCGATATCAGTCTTTCATTGAGCAGCTTGAAGCGCCT
GTACAAAATGTTGAGGGGCGTCAACGCCTGATGGATGTGAAGCCAGAATGGAAATAA