Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 79429..80004 Replicon chromosome
Accession NZ_CP043043
Organism Gluconobacter thailandicus strain HD924

Toxin (Protein)


Gene name mazF Uniprot ID M9LWX6
Locus tag FXF46_RS00430 Protein ID WP_007284171.1
Coordinates 79672..80004 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A061M1V4
Locus tag FXF46_RS00425 Protein ID WP_023945732.1
Coordinates 79429..79671 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXF46_RS00395 74881..75234 - 354 WP_007283494.1 30S ribosomal protein S16 -
FXF46_RS00400 75275..76690 - 1416 WP_061510479.1 signal recognition particle protein -
FXF46_RS00405 76820..77350 - 531 WP_148619173.1 Spy/CpxP family protein refolding chaperone -
FXF46_RS00415 78093..78335 + 243 WP_148619174.1 helix-turn-helix domain-containing protein -
FXF46_RS00425 79429..79671 + 243 WP_023945732.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FXF46_RS00430 79672..80004 + 333 WP_007284171.1 endoribonuclease MazF Toxin
FXF46_RS00435 80149..80733 - 585 WP_023945733.1 hypothetical protein -
FXF46_RS00440 80730..81095 - 366 WP_051400858.1 PadR family transcriptional regulator -
FXF46_RS00445 81408..81953 + 546 WP_148619176.1 hypothetical protein -
FXF46_RS00450 82325..83206 - 882 WP_148619177.1 LysR family transcriptional regulator -
FXF46_RS00455 83320..84195 + 876 WP_148619178.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-106)

Antitoxin

Antitoxin PemI-like

(4-80)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12144.95 Da        Isoelectric Point: 8.2796

>T136990 WP_007284171.1 NZ_CP043043:79672-80004 [Gluconobacter thailandicus]
MSASWVPDCGDIVWLEFDPQAGREQAGHRPAVVLSPADYNKKSGMIVCCPTTTKIKGYPFEVPLAGEPASVVLSDQVRSL
DWRARRAKHKGRVLDSELEAVRERARLLVG

Download         Length: 333 bp

>T136990 NZ_CP056395:c1191925-1191707 [Citrobacter freundii]
ATGTCTGATAAACCATTAACTAAAACAGATTATTTGATGCGTCTTCGACGCTGCCAGACAATTGACACGCTCGAGCGCGT
TATTGAGAAAAATAAATATGAATTGTCCGACAATGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACGATGAATAAGCTGTACGACAAGATTCCAACTTCCGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8614.70 Da        Isoelectric Point: 4.6982

>AT136990 WP_023945732.1 NZ_CP043043:79429-79671 [Gluconobacter thailandicus]
MLGTVRKWGNSAAIRLPANILEAAHLQVNQAVDVREEDGRIIIQPVRPAALSLEALTAAITDDNRHGEVNFGAETGGEVW

Download         Length: 243 bp

>AT136990 NZ_CP043043:79429-79671 [Gluconobacter thailandicus]
ATGCTTGGAACCGTCAGGAAATGGGGAAACAGCGCGGCCATCCGTCTGCCAGCCAATATCCTTGAGGCTGCTCACCTGCA
GGTGAATCAAGCCGTTGATGTCCGCGAAGAAGATGGACGTATTATTATTCAACCCGTTCGACCTGCGGCACTGTCTCTCG
AAGCCTTAACTGCTGCCATCACAGATGATAACCGTCATGGTGAAGTGAATTTTGGGGCCGAAACGGGTGGAGAAGTCTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M9LWX6

Antitoxin

Source ID Structure
AlphaFold DB A0A061M1V4

References