Detailed information of TA system TA136988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 3409248..3409795
• Replicon: chromosome
• Accession: NZ_CP043042
• Organism: Marinobacter fonticola strain CS412

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FXO11_RS15205
• Protein ID: WP_148863772.1
• Coordinates: 3409248..3409550 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U7NTA2
• Locus tag: FXO11_RS15210
• Protein ID: WP_022992576.1
• Coordinates: 3409538..3409795 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXO11_RS15180	3405083..3406039	-	957	WP_148863768.1	LysR family transcriptional regulator	-
FXO11_RS15185	3406180..3406572	+	393	WP_148863769.1	RidA family protein	-
FXO11_RS15190	3406577..3406915	-	339	WP_148863770.1	hypothetical protein	-
FXO11_RS15195	3407514..3408974	+	1461	WP_168203182.1	diguanylate cyclase	-
FXO11_RS15205	3409248..3409550	-	303	WP_148863772.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FXO11_RS15210	3409538..3409795	-	258	WP_022992576.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FXO11_RS15215	3410043..3410237	+	195	WP_148863773.1	type II toxin-antitoxin system VapB family antitoxin	-
FXO11_RS15220	3410234..3410635	+	402	WP_148863774.1	PIN domain nuclease	-
FXO11_RS15225	3410762..3411034	+	273	WP_148863775.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
FXO11_RS15230	3411015..3411287	+	273	WP_148863776.1	Txe/YoeB family addiction module toxin	-
FXO11_RS15235	3411355..3411945	-	591	WP_148863777.1	HEPN domain-containing protein	-
FXO11_RS15240	3412325..3413416	-	1092	WP_148863778.1	TOBE-like domain-containing protein	-
FXO11_RS15245	3413426..3414256	-	831	WP_148863779.1	sulfate ABC transporter permease subunit CysW	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3403032..3411945	8913

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11500.10 Da
• Isoelectric Point: 4.2703

>T136988 WP_148863772.1 NZ_CP043042:c3409550-3409248 [Marinobacter fonticola]
MAEVIWAEPALQALDAIAEYIALDNSAAASDLVQEVLNKTERLEDFPQSGRIPPELPNSVYREVVVPPCRIFYREDQQRV
FVLYVMRDERQLRAYMLGNS

Nucleotide

• Length: 303 bp

>T136988 NZ_CP043042:c3409550-3409248 [Marinobacter fonticola]
ATGGCTGAAGTAATCTGGGCAGAGCCCGCTCTTCAAGCACTGGATGCTATCGCTGAGTACATTGCTCTGGATAATTCTGC
GGCCGCAAGCGACCTAGTTCAAGAAGTTTTAAACAAGACCGAGCGTTTGGAAGATTTTCCCCAATCCGGACGGATTCCCC
CAGAGCTCCCGAATTCGGTATACAGGGAGGTAGTGGTTCCACCGTGTCGTATTTTTTATCGTGAGGATCAACAGCGGGTT
TTTGTCCTCTACGTCATGCGAGATGAGCGGCAGCTTCGTGCATACATGCTTGGAAACAGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9901.44 Da
• Isoelectric Point: 8.5042

>AT136988 WP_022992576.1 NZ_CP043042:c3409795-3409538 [Marinobacter fonticola]
MKVELVTNLKRQATKILADLHLSKEPILITEHGQPSAYLVDVQDYEFMQRRLELLEGLSRGERAVLEGRTYSQSEAREKM
SKWLK

Nucleotide

• Length: 258 bp

>AT136988 NZ_CP043042:c3409795-3409538 [Marinobacter fonticola]
ATGAAAGTTGAGCTTGTTACGAATCTCAAACGCCAAGCCACAAAGATTCTGGCAGATCTGCACTTGTCTAAAGAGCCGAT
ACTGATTACGGAGCATGGTCAGCCGTCCGCCTACCTTGTCGATGTTCAGGATTACGAGTTTATGCAGCGTCGACTTGAGC
TGCTTGAAGGGCTCTCTCGGGGAGAGCGTGCTGTACTTGAGGGAAGAACGTACAGCCAAAGTGAGGCCAGGGAGAAAATG
AGTAAATGGCTGAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A455VBQ8