Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | chpIK/PemK(toxin) |
Location | 1032173..1032749 | Replicon | chromosome |
Accession | NZ_CP043041 | ||
Organism | Leptospira interrogans serovar Hardjo strain L53 |
Toxin (Protein)
Gene name | chpK | Uniprot ID | Q93MT8 |
Locus tag | FWJ33_RS06560 | Protein ID | WP_000617906.1 |
Coordinates | 1032408..1032749 (+) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | chpI | Uniprot ID | Q93MT9 |
Locus tag | FWJ33_RS06555 | Protein ID | WP_000844758.1 |
Coordinates | 1032173..1032421 (+) | Length | 83 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FWJ33_RS06540 | 1027824..1029806 | + | 1983 | WP_000836894.1 | GAF domain-containing protein | - |
FWJ33_RS21220 | 1030448..1030906 | - | 459 | WP_000453267.1 | hypothetical protein | - |
FWJ33_RS06550 | 1031060..1031356 | + | 297 | WP_000477061.1 | helix-turn-helix domain-containing protein | - |
FWJ33_RS06555 | 1032173..1032421 | + | 249 | WP_000844758.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
FWJ33_RS06560 | 1032408..1032749 | + | 342 | WP_000617906.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
FWJ33_RS06565 | 1033844..1034356 | + | 513 | WP_000079224.1 | VOC family protein | - |
FWJ33_RS06570 | 1035040..1035633 | + | 594 | WP_001226990.1 | dihydrofolate reductase family protein | - |
FWJ33_RS06575 | 1035705..1036592 | + | 888 | WP_002188401.1 | hypothetical protein | - |
FWJ33_RS06580 | 1036710..1037456 | + | 747 | WP_000617027.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12372.25 Da Isoelectric Point: 6.3272
>T136983 WP_000617906.1 NZ_CP043041:1032408-1032749 [Leptospira interrogans serovar Hardjo]
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVFISKKDSSLSKDSVINVSQIV
TLDKERFLNKAGKLKSNKLGEVEIGLKLVTGLD
MIRGEIWWVDLGIPFGSEPGFKRPVLIIQDDSFNQSNINTIVSIAITSNLNLSEAPGNVFISKKDSSLSKDSVINVSQIV
TLDKERFLNKAGKLKSNKLGEVEIGLKLVTGLD
Download Length: 342 bp
>T136983 NZ_CP043041:1032408-1032749 [Leptospira interrogans serovar Hardjo]
ATGATTCGTGGTGAAATTTGGTGGGTAGATTTGGGAATTCCATTTGGAAGTGAGCCTGGATTTAAACGTCCAGTTCTTAT
AATTCAAGATGACTCTTTTAATCAAAGTAATATTAATACAATAGTTTCGATTGCAATTACATCGAATTTAAATCTATCTG
AAGCACCAGGTAATGTTTTCATTAGTAAAAAAGATTCGAGTTTATCAAAGGACTCGGTCATAAATGTCTCTCAAATTGTG
ACTTTAGATAAAGAAAGATTTCTTAACAAAGCGGGTAAACTTAAATCAAATAAATTAGGTGAAGTTGAAATTGGGCTTAA
GTTGGTTACAGGCTTAGATTGA
ATGATTCGTGGTGAAATTTGGTGGGTAGATTTGGGAATTCCATTTGGAAGTGAGCCTGGATTTAAACGTCCAGTTCTTAT
AATTCAAGATGACTCTTTTAATCAAAGTAATATTAATACAATAGTTTCGATTGCAATTACATCGAATTTAAATCTATCTG
AAGCACCAGGTAATGTTTTCATTAGTAAAAAAGATTCGAGTTTATCAAAGGACTCGGTCATAAATGTCTCTCAAATTGTG
ACTTTAGATAAAGAAAGATTTCTTAACAAAGCGGGTAAACTTAAATCAAATAAATTAGGTGAAGTTGAAATTGGGCTTAA
GTTGGTTACAGGCTTAGATTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9380.77 Da Isoelectric Point: 10.3815
>AT136983 WP_000844758.1 NZ_CP043041:1032173-1032421 [Leptospira interrogans serovar Hardjo]
MKTAISIPDELFRAAEKIAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYSNKSKETRNNITDLSVESLRKSLKND
SW
MKTAISIPDELFRAAEKIAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYSNKSKETRNNITDLSVESLRKSLKND
SW
Download Length: 249 bp
>AT136983 NZ_CP056393:c4015586-4015320 [Enterobacter sp. RHBSTW-00593]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACAGCTTAAGCGATGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCTGATT
TATTTAACTGGCTGATGAATCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M4MS74 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0F6HD92 |