Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4617473..4618271 Replicon chromosome
Accession NZ_CP043033
Organism Escherichia coli strain XDL

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag EOV66_RS22520 Protein ID WP_000854735.1
Coordinates 4617894..4618271 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag EOV66_RS22515 Protein ID WP_032153712.1
Coordinates 4617473..4617847 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOV66_RS22480 4613206..4614090 + 885 WP_024166630.1 50S ribosome-binding GTPase -
EOV66_RS22485 4614209..4614886 + 678 WP_023155728.1 hypothetical protein -
EOV66_RS22490 4614916..4615125 + 210 WP_023155727.1 DUF905 family protein -
EOV66_RS22495 4615216..4616034 + 819 WP_001234693.1 DUF945 domain-containing protein -
EOV66_RS22500 4616126..4616611 + 486 WP_032153711.1 antirestriction protein -
EOV66_RS22505 4616627..4617103 + 477 WP_001186715.1 RadC family protein -
EOV66_RS22510 4617172..4617393 + 222 WP_000692345.1 DUF987 domain-containing protein -
EOV66_RS22515 4617473..4617847 + 375 WP_032153712.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
EOV66_RS22520 4617894..4618271 + 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
EOV66_RS22525 4618268..4618759 + 492 WP_023155722.1 hypothetical protein -
EOV66_RS22530 4618771..4618968 + 198 WP_000839265.1 DUF957 domain-containing protein -
EOV66_RS22535 4619053..4619919 + 867 WP_032153714.1 DUF4942 domain-containing protein -
EOV66_RS22540 4619991..4620254 + 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
EOV66_RS22545 4620251..4620577 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
EOV66_RS22550 4621460..4622998 + 1539 WP_001187186.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 papB / papI 4556391..4630811 74420


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T136977 WP_000854735.1 NZ_CP043033:4617894-4618271 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T136977 NZ_CP056386:57792-58274 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT136977 WP_032153712.1 NZ_CP043033:4617473-4617847 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT136977 NZ_CP043033:4617473-4617847 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References