Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3713354..3713972 Replicon chromosome
Accession NZ_CP043033
Organism Escherichia coli strain XDL

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag EOV66_RS18085 Protein ID WP_001291435.1
Coordinates 3713754..3713972 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag EOV66_RS18080 Protein ID WP_000344800.1
Coordinates 3713354..3713728 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EOV66_RS18070 3708443..3709636 + 1194 WP_096884770.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EOV66_RS18075 3709659..3712808 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
EOV66_RS18080 3713354..3713728 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
EOV66_RS18085 3713754..3713972 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
EOV66_RS18090 3714144..3714695 + 552 WP_000102561.1 maltose O-acetyltransferase -
EOV66_RS18095 3714811..3715281 + 471 WP_000136192.1 YlaC family protein -
EOV66_RS18100 3715445..3716995 + 1551 WP_012311818.1 cyclic-guanylate-specific phosphodiesterase PdeB -
EOV66_RS18105 3717036..3717389 - 354 WP_000878140.1 DUF1428 domain-containing protein -
EOV66_RS18115 3717768..3718079 + 312 WP_000409911.1 MGMT family protein -
EOV66_RS18120 3718110..3718682 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T136973 WP_001291435.1 NZ_CP043033:3713754-3713972 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T136973 NZ_CP043033:3713754-3713972 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACTATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT136973 WP_000344800.1 NZ_CP043033:3713354-3713728 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT136973 NZ_CP056385:c5222211-5221969 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References