Detailed information of TA system TA136950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 459562..460147
• Replicon: chromosome
• Accession: NZ_CP043028
• Organism: Pseudobutyrivibrio xylanivorans strain MA3014

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FXF36_RS02080
• Protein ID: WP_202880052.1
• Coordinates: 459938..460147 (-)
• Length: 70 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FXF36_RS02075
• Protein ID: WP_151622237.1
• Coordinates: 459562..459897 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXF36_RS02065	455799..458201	-	2403	WP_151622235.1	ribonucleoside triphosphate reductase	-
FXF36_RS02070	458542..459495	-	954	WP_151622236.1	tetratricopeptide repeat protein	-
FXF36_RS02075	459562..459897	-	336	WP_151622237.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FXF36_RS02080	459938..460147	-	210	WP_202880052.1	type II toxin-antitoxin system HicA family toxin	Toxin
FXF36_RS02085	460268..461542	+	1275	WP_151622238.1	hemolysin family protein	-
FXF36_RS02090	461505..462131	-	627	WP_151622239.1	hypothetical protein	-
FXF36_RS02095	462360..462881	-	522	WP_151622240.1	peptidylprolyl isomerase	-
FXF36_RS02100	463077..463955	-	879	WP_151622241.1	Mrp/NBP35 family ATP-binding protein	-
FXF36_RS02105	464326..465102	+	777	WP_151622242.1	threonine/serine exporter family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-69)

Antitoxin

• Uncharacterised protein family HicB (52-102)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 8058.22 Da
• Isoelectric Point: 10.2030

>T136950 WP_202880052.1 NZ_CP043028:c460147-459938 [Pseudobutyrivibrio xylanivorans]
MNNKDKKILRDIFYNPIRSDIKWSDIEHLFILLGGKVTEGNGSRVRVELNKERAVFHRPHPENTTDKGL

Nucleotide

• Length: 210 bp

>T136950 NZ_CP056366:99501-99812 [Citrobacter freundii]
ATGCACGTTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12869.62 Da
• Isoelectric Point: 4.6325

>AT136950 WP_151622237.1 NZ_CP043028:c459897-459562 [Pseudobutyrivibrio xylanivorans]
MMNYKGYIGKVEFDDEQHIFVGEVINTRTVITFQGSSVKELEEEFKNSVEDYLEWCKEDGVEYEKPYSGKFNVRINPQLH
QRAAVGAKMLGMSLNSFLIKSLEDELNLMHI

Nucleotide

• Length: 336 bp

>AT136950 NZ_CP043028:c459897-459562 [Pseudobutyrivibrio xylanivorans]
ATGATGAACTATAAGGGTTATATTGGAAAAGTAGAGTTTGATGATGAACAGCATATTTTTGTGGGCGAAGTTATAAATAC
AAGGACTGTTATTACTTTTCAGGGTTCTTCTGTAAAAGAGCTTGAGGAGGAGTTCAAAAATTCTGTTGAGGATTATTTGG
AATGGTGTAAGGAAGATGGTGTGGAGTATGAAAAGCCATATTCTGGAAAGTTTAATGTGAGAATTAATCCTCAGCTTCAT
CAGAGAGCAGCAGTTGGTGCCAAGATGCTGGGGATGTCTCTGAACTCTTTTTTGATAAAATCCTTAGAGGATGAACTGAA
TTTAATGCATATTTAG