136947

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3580600..3581220 Replicon chromosome
Accession NZ_CP043009
Organism Citrobacter portucalensis strain WCHCP085039

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag FXN82_RS17920 Protein ID WP_002892050.1
Coordinates 3581002..3581220 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag FXN82_RS17915 Protein ID WP_003021733.1
Coordinates 3580600..3580974 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN82_RS17905 3575747..3576940 + 1194 WP_148362334.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FXN82_RS17910 3576963..3580112 + 3150 WP_063941319.1 efflux RND transporter permease AcrB -
FXN82_RS17915 3580600..3580974 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
FXN82_RS17920 3581002..3581220 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
FXN82_RS17925 3581402..3581953 + 552 WP_148362335.1 maltose O-acetyltransferase -
FXN82_RS17930 3582070..3582540 + 471 WP_020996574.1 YlaC family protein -
FXN82_RS17935 3582619..3582759 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
FXN82_RS17940 3582761..3583021 - 261 WP_003021719.1 type B 50S ribosomal protein L31 -
FXN82_RS17945 3583210..3584763 + 1554 WP_148362336.1 EAL domain-containing protein -
FXN82_RS17950 3584815..3585168 - 354 WP_003831033.1 DUF1428 family protein -
FXN82_RS17955 3585233..3585862 - 630 WP_148362337.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T136947 WP_002892050.1 NZ_CP043009:3581002-3581220 [Citrobacter portucalensis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T136947 NZ_CP056365:c4429296-4429012 [Citrobacter freundii]
ATGACTTATGAACTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATACGGTGAAGGCTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCAGATTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGACCGTGTTTGTTGTCGCGGTCGGCAAG
CGACAACATTCGGCCGTTTATCTCGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT136947 WP_003021733.1 NZ_CP043009:3580600-3580974 [Citrobacter portucalensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT136947 NZ_CP043009:3580600-3580974 [Citrobacter portucalensis]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References