136946

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2488669..2489405 Replicon chromosome
Accession NZ_CP043009
Organism Citrobacter portucalensis strain WCHCP085039

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag FXN82_RS12590 Protein ID WP_148361982.1
Coordinates 2488923..2489405 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag FXN82_RS12585 Protein ID WP_008784769.1
Coordinates 2488669..2488935 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN82_RS12565 2483721..2484908 + 1188 WP_148361980.1 outer membrane protein transport protein -
FXN82_RS12570 2485146..2485775 + 630 WP_003832974.1 winged helix-turn-helix transcriptional regulator -
FXN82_RS12575 2485892..2486278 - 387 WP_063941972.1 hypothetical protein -
FXN82_RS12580 2486533..2488515 + 1983 WP_148361981.1 MBL fold metallo-hydrolase -
FXN82_RS12585 2488669..2488935 + 267 WP_008784769.1 DUF1778 domain-containing protein Antitoxin
FXN82_RS12590 2488923..2489405 + 483 WP_148361982.1 GNAT family N-acetyltransferase Toxin
FXN82_RS12595 2489651..2490058 - 408 Protein_2302 mechanosensitive ion channel protein MscS -
FXN82_RS12600 2490438..2490815 + 378 WP_148361983.1 hypothetical protein -
FXN82_RS12605 2490869..2491705 + 837 WP_003832960.1 DMT family transporter -
FXN82_RS12610 2491715..2492236 - 522 WP_148362673.1 GNAT family N-acetyltransferase -
FXN82_RS12615 2492347..2493105 + 759 WP_148361984.1 trans-aconitate 2-methyltransferase -
FXN82_RS12620 2493237..2493614 + 378 WP_003832953.1 GFA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17585.40 Da        Isoelectric Point: 9.5608

>T136946 WP_148361982.1 NZ_CP043009:2488923-2489405 [Citrobacter portucalensis]
VGFVTAPEPLTHIHQLAEFVSGEIVLDDWLKQKGLKNQALGAARTFVVCKTDTRQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSVRGKGLGADLLHDAVLRCYKVAENIGVRAVMVHALTDEAKRFYLHHGFKASQLQERTLFLKLS

Download         Length: 483 bp

>T136946 NZ_CP056365:c4362640-4362299 [Citrobacter freundii]
ATGAAAACTCTACCTGCAACAAATCCGCAGGTGGCGACGCTATGTCTGTCGCCCGTGGCGGTCTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTATGGGCTGGTTCGTATTGATCGTAGGGGATTC
GACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGCATTAGCGCGGCACGGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10159.65 Da        Isoelectric Point: 4.6558

>AT136946 WP_008784769.1 NZ_CP043009:2488669-2488935 [Citrobacter portucalensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIEMLDAPVAEDPAIRKLL
ARKPQWDL

Download         Length: 267 bp

>AT136946 NZ_CP043009:2488669-2488935 [Citrobacter portucalensis]
ATGAAATCAGATGTCCAGCTCAACCTTAGAGCTAAAGAATCCCAACGCGCGCTTATTGATGCGGCCGCAGAGATTCTACA
TAAATCGCGTACAGACTTTATTCTGGAAATGGCCTGCCAGGCGGCAGAGAACGTTATTCTCGATCGCCGAGTGTTTAATT
TTAATGATGAACAATACGCTGAGTTTATCGAGATGCTTGATGCTCCGGTTGCCGAAGATCCCGCTATCAGGAAGCTACTG
GCAAGGAAACCACAGTGGGATTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References