Detailed information of TA system TA136937

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 1250339..1251081
• Replicon: chromosome
• Accession: NZ_CP043009
• Organism: Citrobacter portucalensis strain WCHCP085039

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: FXN82_RS06690
• Protein ID: WP_148361598.1
• Coordinates: 1250339..1250659 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: FXN82_RS06695
• Protein ID: WP_148361599.1
• Coordinates: 1250716..1251081 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXN82_RS06665	1246503..1247393	+	891	WP_003826107.1	myo-inosose-2 dehydratase	-
FXN82_RS06670	1247403..1248221	+	819	WP_148361597.1	5-deoxy-glucuronate isomerase	-
FXN82_RS06675	1248416..1248772	-	357	WP_003826111.1	hypothetical protein	-
FXN82_RS06680	1248944..1249408	-	465	WP_187392915.1	hypothetical protein	-
FXN82_RS06690	1250339..1250659	-	321	WP_148361598.1	TA system toxin CbtA family protein	Toxin
FXN82_RS06695	1250716..1251081	-	366	WP_148361599.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
FXN82_RS06700	1251104..1251325	-	222	WP_148361600.1	DUF987 domain-containing protein	-
FXN82_RS06705	1251336..1251815	-	480	WP_148361601.1	DNA repair protein RadC	-
FXN82_RS06710	1251826..1252290	-	465	WP_148361602.1	antirestriction protein	-
FXN82_RS06715	1252429..1253247	-	819	WP_148361603.1	DUF945 domain-containing protein	-
FXN82_RS06720	1253360..1253803	-	444	WP_148361604.1	hypothetical protein	-
FXN82_RS06725	1253816..1254415	-	600	WP_148361605.1	hypothetical protein	-
FXN82_RS06730	1254852..1255739	-	888	WP_148361606.1	50S ribosome-binding GTPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1250339..1271974	21635

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-101)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 11918.60 Da
• Isoelectric Point: 5.0359

>T136937 WP_148361598.1 NZ_CP043009:c1250659-1250339 [Citrobacter portucalensis]
MQTLSAIPVRKAPPRPTPVETWQQLLAYLLEQHYGLSLNDTPFSDEQTIKQHIEAGISLADGVNFLVEQYELVRTDHKGI
SWQAQSPFITATDILIAKRALVEMST

Nucleotide

• Length: 321 bp

>T136937 NZ_CP056329:c4867827-4866910 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGGAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13410.35 Da
• Isoelectric Point: 7.3196

>AT136937 WP_148361599.1 NZ_CP043009:c1251081-1250716 [Citrobacter portucalensis]
MQKTTPVANHDIAKPWWGLKLAVTPSFGARLVQEENQLHYLADRASIAGTFSDADLRHLDQAFPVLLKQLELMLVSGELN
PRQQRGVTLYAKGLTCDADTLGSCGYLYITIYPTSGNRIPH

Nucleotide

• Length: 366 bp

>AT136937 NZ_CP056329:c4868591-4867833 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA