Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 714270..715893 Replicon chromosome
Accession NZ_CP043009
Organism Citrobacter portucalensis strain WCHCP085039

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag FXN82_RS04130 Protein ID WP_103798313.1
Coordinates 714568..715893 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag FXN82_RS04125 Protein ID WP_148362656.1
Coordinates 714270..714563 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN82_RS04100 709595..712603 - 3009 WP_148361456.1 Tn3 family transposase -
FXN82_RS04105 712762..712890 + 129 Protein_672 recombinase family protein -
FXN82_RS04110 712950..713198 + 249 Protein_673 transposase -
FXN82_RS04115 713263..713592 + 330 Protein_674 IS30 family transposase -
FXN82_RS04120 713591..713869 + 279 Protein_675 hypothetical protein -
FXN82_RS04125 714270..714563 + 294 WP_148362656.1 helix-turn-helix transcriptional regulator Antitoxin
FXN82_RS04130 714568..715893 + 1326 WP_103798313.1 type II toxin-antitoxin system HipA family toxin Toxin
FXN82_RS04135 715954..716160 + 207 WP_000134171.1 hypothetical protein -
FXN82_RS04140 716262..716672 + 411 WP_000985911.1 hypothetical protein -
FXN82_RS04145 716685..717500 + 816 WP_001572439.1 HNH endonuclease -
FXN82_RS04150 717583..718362 + 780 Protein_681 IS5-like element ISKpn26 family transposase -
FXN82_RS04155 718446..718886 + 441 WP_004189163.1 IS66 family insertion sequence hypothetical protein -
FXN82_RS04160 718883..719233 + 351 WP_004189161.1 IS66 family insertion sequence element accessory protein TnpB -
FXN82_RS04165 719264..720856 + 1593 WP_004902302.1 IS66-like element ISKox1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 686516..729105 42589
- inside IScluster/Tn - - 709595..720856 11261


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-404)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-70)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50333.27 Da        Isoelectric Point: 5.8810

>T136933 WP_103798313.1 NZ_CP043009:714568-715893 [Citrobacter portucalensis]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWYEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLDQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T136933 NZ_CP043009:714568-715893 [Citrobacter portucalensis]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTCCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGTATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGACCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCTTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11016.43 Da        Isoelectric Point: 9.9492

>AT136933 WP_148362656.1 NZ_CP043009:714270-714563 [Citrobacter portucalensis]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSVLGVKISFSSPTTSSERK
QTEEIYKLNSPARQEDW

Download         Length: 294 bp

>AT136933 NZ_CP043009:714270-714563 [Citrobacter portucalensis]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGTTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGTGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCGTCCTGGGTGTAAAAATCAGCTTCTCCTCGCCAACCACTTCTTCAGAGAGGAAG
CAGACGGAAGAAATATATAAATTAAATTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References