Detailed information of TA system TA136929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 1971267..1971920
• Replicon: chromosome
• Accession: NZ_CP043005
• Organism: Aggregatibacter actinomycetemcomitans strain PN_696

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FXN57_RS10170
• Protein ID: WP_148324358.1
• Coordinates: 1971267..1971449 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FXN57_RS10175
• Protein ID: WP_148324355.1
• Coordinates: 1971501..1971920 (+)
• Length: 140 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXN57_RS12375	1967145..1967597	+	453	Protein_1949	ribose ABC transporter permease	-
FXN57_RS10155 (FXN57_10150)	1967615..1968529	-	915	WP_262404649.1	baseplate J/gp47 family protein	-
FXN57_RS10160 (FXN57_10155)	1968656..1969555	-	900	WP_148363571.1	BRO family protein	-
FXN57_RS10165 (FXN57_10160)	1969862..1971013	-	1152	WP_148324361.1	type I restriction endonuclease	-
FXN57_RS10170 (FXN57_10165)	1971267..1971449	+	183	WP_148324358.1	type II toxin-antitoxin system HicA family toxin	Toxin
FXN57_RS10175 (FXN57_10170)	1971501..1971920	+	420	WP_148324355.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FXN57_RS10180 (FXN57_10175)	1971946..1972305	-	360	WP_005545972.1	hypothetical protein	-
FXN57_RS10185 (FXN57_10180)	1972302..1972946	-	645	WP_148324351.1	Gp138 family membrane-puncturing spike protein	-
FXN57_RS10190 (FXN57_10185)	1973232..1973363	+	132	WP_257210258.1	hypothetical protein	-
FXN57_RS10195 (FXN57_10190)	1973397..1973822	+	426	WP_148324348.1	hypothetical protein	-
FXN57_RS10200 (FXN57_10195)	1974131..1974445	+	315	WP_015971210.1	hypothetical protein	-
FXN57_RS10205 (FXN57_10200)	1974485..1974808	+	324	WP_233113734.1	helix-turn-helix domain-containing protein	-
FXN57_RS10210 (FXN57_10205)	1974721..1975728	+	1008	WP_262404690.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1956163..1975728	19565

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-63)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6964.14 Da
• Isoelectric Point: 10.0109

>T136929 WP_148324358.1 NZ_CP043005:1971267-1971449 [Aggregatibacter actinomycetemcomitans]
MKYSEFLRYLLEQGCKVEATKRGSYRKVTLNDCQTVFPYHGSKEIGTGLVHKIKKDLNLK

Nucleotide

• Length: 183 bp

>T136929 NZ_CP043005:1971267-1971449 [Aggregatibacter actinomycetemcomitans]
ATGAAATACAGTGAATTCTTGCGATACTTGCTTGAGCAAGGCTGCAAAGTCGAAGCAACCAAGCGCGGAAGTTATCGCAA
GGTAACGTTGAATGACTGCCAAACTGTCTTTCCCTACCATGGTAGTAAAGAAATCGGTACCGGCTTAGTTCACAAAATCA
AAAAAGACTTAAACTTAAAATAA

Antitoxin

Protein

• Length: 140 a.a.
• Molecular weight: 15826.24 Da
• Isoelectric Point: 4.6005

>AT136929 WP_148324355.1 NZ_CP043005:1971501-1971920 [Aggregatibacter actinomycetemcomitans]
MLRYPVEITPDDNGTFLVTCPDIPEMASVGEDIESALLEAEEGLETALEFYFDDKRPIPMPSQPTDGQYTVPLSLLRSLK
VFLLNEMLAQGVRKAEMARRLDVHIPQVDRLLDFRHPSKIDFVEKAFKKLGREINLSVH

Nucleotide

• Length: 420 bp

>AT136929 NZ_CP056329:353609-353908 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA