Detailed information of TA system TA136928

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1779018..1779552
• Replicon: chromosome
• Accession: NZ_CP043005
• Organism: Aggregatibacter actinomycetemcomitans strain PN_696

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FXN57_RS09185
• Protein ID: WP_148325094.1
• Coordinates: 1779262..1779552 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FXN57_RS09180
• Protein ID: WP_005545663.1
• Coordinates: 1779018..1779272 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXN57_RS09150 (FXN57_09145)	1774746..1775843	+	1098	WP_148325102.1	histidinol-phosphate transaminase	-
FXN57_RS09155 (FXN57_09150)	1775854..1777185	+	1332	WP_148325100.1	3-phosphoshikimate 1-carboxyvinyltransferase	-
FXN57_RS09160 (FXN57_09155)	1777273..1777740	-	468	WP_148325098.1	ribonuclease HI	-
FXN57_RS09165 (FXN57_09160)	1777808..1778569	+	762	WP_148325096.1	DNA polymerase III subunit epsilon	-
FXN57_RS09180 (FXN57_09175)	1779018..1779272	+	255	WP_005545663.1	stability protein StbD	Antitoxin
FXN57_RS09185 (FXN57_09180)	1779262..1779552	+	291	WP_148325094.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FXN57_RS09190 (FXN57_09185)	1779614..1779952	-	339	WP_148325092.1	cupin domain-containing protein	-
FXN57_RS09195 (FXN57_09190)	1780291..1781352	+	1062	WP_148325091.1	YedE family putative selenium transporter	-
FXN57_RS09200 (FXN57_09195)	1781524..1782912	+	1389	WP_148325089.1	tRNA 5-hydroxyuridine modification protein YegQ	-
FXN57_RS09205 (FXN57_09200)	1783209..1784300	+	1092	WP_148363532.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11510.33 Da
• Isoelectric Point: 10.6313

>T136928 WP_148325094.1 NZ_CP043005:1779262-1779552 [Aggregatibacter actinomycetemcomitans]
MTYKLTFDKRALKEWEKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Nucleotide

• Length: 291 bp

>T136928 NZ_CP043005:1779262-1779552 [Aggregatibacter actinomycetemcomitans]
ATGACTTATAAACTCACTTTTGATAAAAGGGCTTTAAAAGAGTGGGAAAAGTTAGGCGATACCATACGCCAACAATTCAA
AAATAAACTTGCGGAACGCTTAGAAAATCCGAGAGTACCCGGCGACAAATTAAGGGGTTATCAAAACCTTTATAAAATCA
AACTCCGCGCTGCCGGTTATCGCTTAGTTTATGAAGTTAATGATAACCAAATTTATATTCTTGTTTTATCCGTGGGTAAA
CGAAACAGATTAGACGCATACAAAAACGCAGAATTCAGACAAGCCCGGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9294.53 Da
• Isoelectric Point: 3.9649

>AT136928 WP_005545663.1 NZ_CP043005:1779018-1779272 [Aggregatibacter actinomycetemcomitans]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNRNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Nucleotide

• Length: 255 bp

>AT136928 NZ_CP043005:1779018-1779272 [Aggregatibacter actinomycetemcomitans]
ATGGCAATACATCAAATTTTGACACAGCAAGCCGCAAGCATTACCGATTTAAAACGGGACCCTATGGGTATTGCGTACGC
AAGCCAAGATGGTGCCGTAGCCATATTAAACCGTAACCAACCTGCCTTTTATTGCGTCACGCCTGCATTATTTGAATATT
TTCAAAATCTGGTAGAAGATGCAGAATTAGGCAGAATTGCTGAAGAGCGTCTGGCAACCCTTGATCCGATTGAGGTAAGC
CTCGATGACTTATAA