136927

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1745620..1746170 Replicon chromosome
Accession NZ_CP043005
Organism Aggregatibacter actinomycetemcomitans strain PN_696

Toxin (Protein)


Gene name relE Uniprot ID G4A7B4
Locus tag FXN57_RS09020 Protein ID WP_005539226.1
Coordinates 1745904..1746170 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID X2JQ67
Locus tag FXN57_RS09015 Protein ID WP_005539223.1
Coordinates 1745620..1745892 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN57_RS08980 (FXN57_08975) 1741492..1742133 + 642 WP_005546457.1 cytochrome c biogenesis protein CcdA -
FXN57_RS08985 (FXN57_08980) 1742148..1742630 + 483 WP_005552667.1 redoxin family protein -
FXN57_RS09000 (FXN57_08995) 1743464..1743637 + 174 WP_005552670.1 hypothetical protein -
FXN57_RS09005 (FXN57_09000) 1744013..1745365 + 1353 WP_148363524.1 anaerobic C4-dicarboxylate transporter DcuC -
FXN57_RS09015 (FXN57_09010) 1745620..1745892 + 273 WP_005539223.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FXN57_RS09020 (FXN57_09015) 1745904..1746170 + 267 WP_005539226.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
FXN57_RS09025 (FXN57_09020) 1746202..1747761 + 1560 WP_148363525.1 glutamine-hydrolyzing GMP synthase -
FXN57_RS09030 (FXN57_09025) 1748154..1749104 - 951 WP_148325130.1 hypothetical protein -
FXN57_RS09035 (FXN57_09030) 1749298..1749711 - 414 WP_032996591.1 hydroxyisourate hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10502.03 Da        Isoelectric Point: 7.2393

>T136927 WP_005539226.1 NZ_CP043005:1745904-1746170 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLVLIYKIEADTLYFARL
NSHSEVFK

Download         Length: 267 bp

>T136927 NZ_CP056314:c4808260-4807886 [Citrobacter freundii]
ATGGTCAAAGGATCCGCGCTTTTTGATACCAACATCCTCATCGATCTGTTTAGTGGGAGAAATGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAATGCAATCAGCCTCATTACATGGATGGAGGTGATGGTGGGTGCAAAAAAATACCATCAGG
AAGCCCGTACTCGTGTTGCGCTAGGTGCTTTTAACGTGATCGGCGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGACAGGAATATGGGATGAAATTGCCGGATGCCATTATTTTGGCAACAGCACAGATTCATCGTCTTACGCTGGTTACGCG
AAATACTAAGGATTTTGCAGGCCTATCCGGTGTGGTCACACCGTATACATTATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10147.52 Da        Isoelectric Point: 6.2633

>AT136927 WP_005539223.1 NZ_CP043005:1745620-1745892 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Download         Length: 273 bp

>AT136927 NZ_CP043005:1745620-1745892 [Aggregatibacter actinomycetemcomitans]
ATGTTAGATAGCGCAGTGAATTTCCGTACTCAAGCCGACATCAAAGAGCAAGCGTTTAACGTCATTAAAAGCTATGGCTT
AACGCCCGCTCAGGTGTTAAATATGTTTTTGACCCAAATTGCCAAAACCAACACAATTCCGCTCAGTTTGGATTATCAGC
CGAATACAAAAACAGCTAATGCAATCAATGAATTAATGAGCGGAAAAGGGGAAAGATTTAGCGTAGATTCCTTTGATGAA
TTTCAACAAAAAATTCGTGATTTAAGCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FY83

Antitoxin

Source ID Structure
AlphaFold DB X2JQ67

References