Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YefM-YoeB
Location 1635491..1635993 Replicon chromosome
Accession NZ_CP043005
Organism Aggregatibacter actinomycetemcomitans strain PN_696

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FXN57_RS08470 Protein ID WP_148325252.1
Coordinates 1635491..1635742 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FXN57_RS08475 Protein ID WP_148325251.1
Coordinates 1635739..1635993 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN57_RS08450 (FXN57_08445) 1631108..1631881 - 774 WP_187373635.1 glycosyltransferase family 25 protein -
FXN57_RS08455 (FXN57_08450) 1631943..1632710 - 768 WP_148363065.1 IS5 family transposase -
FXN57_RS08460 (FXN57_08455) 1632906..1634429 + 1524 WP_148325254.1 polysaccharide biosynthesis protein -
FXN57_RS08465 (FXN57_08460) 1634426..1635382 + 957 WP_148327348.1 polysaccharide pyruvyl transferase family protein -
FXN57_RS08470 (FXN57_08465) 1635491..1635742 + 252 WP_148325252.1 type II toxin-antitoxin system prevent-host-death family antitoxin Toxin
FXN57_RS08475 (FXN57_08470) 1635739..1635993 + 255 WP_148325251.1 Txe/YoeB family addiction module toxin Antitoxin
FXN57_RS08480 (FXN57_08475) 1636006..1636749 + 744 WP_148325250.1 YdcF family protein -
FXN57_RS08485 (FXN57_08480) 1636926..1637753 + 828 WP_148325249.1 DNA ligase -
FXN57_RS08490 (FXN57_08485) 1637886..1640060 - 2175 WP_148327347.1 DNA helicase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1631943..1632710 767


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(1-84)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9378.66 Da        Isoelectric Point: 5.0637

>T136925 WP_148325252.1 NZ_CP043005:1635491-1635742 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLAAIDQLNSGKIIERE
LQE

Download         Length: 252 bp

>T136925 NZ_CP043005:1635491-1635742 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCATTCCGTGCAGAATTAGCAACAACACTTGATCAGGTGGTTGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGTAGTCCAAAAAATAGAGAGCGTTTATTAGCCGCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 10216.77 Da        Isoelectric Point: 9.7542

>AT136925 WP_148325251.1 NZ_CP043005:1635739-1635993 [Aggregatibacter actinomycetemcomitans]
MILAWTKTAWEDYLYWQQVDKKTLLRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Download         Length: 255 bp

>AT136925 NZ_CP056314:c4555776-4555435 [Citrobacter freundii]
ATGAAACAGGCAACCAGAAAACCAACGACTGTGGGTGATATCCTGCAATATGAATACCTGGAGCCGCTCGGACTGAAAAT
TAACGATCTGGCTGAAATACTGCATGTTCATCGCAATACGGTGAGCGCACTGGTCAACAATAATCGCAAATTAACAACGG
ATATGGCGTTTCGTTTGGCCAAAGCGTTCGATACCTCCGTTGATTTCTGGCGTAACTTACAGGCGGCGGTTGACCTGTGG
GAAGTTGAAAATGACATGCGGGCGCAAGAAGAACTGAACCGCATTGTTTCGGTTAAAGATTTTATCGCTCAGCGAAATAG
CGAGTCTAAAAAAGTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References