Detailed information of TA system TA136925

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YefM-YoeB
• Location: 1635491..1635993
• Replicon: chromosome
• Accession: NZ_CP043005
• Organism: Aggregatibacter actinomycetemcomitans strain PN_696

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FXN57_RS08470
• Protein ID: WP_148325252.1
• Coordinates: 1635491..1635742 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FXN57_RS08475
• Protein ID: WP_148325251.1
• Coordinates: 1635739..1635993 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXN57_RS08450 (FXN57_08445)	1631108..1631881	-	774	WP_187373635.1	glycosyltransferase family 25 protein	-
FXN57_RS08455 (FXN57_08450)	1631943..1632710	-	768	WP_148363065.1	IS5 family transposase	-
FXN57_RS08460 (FXN57_08455)	1632906..1634429	+	1524	WP_148325254.1	polysaccharide biosynthesis protein	-
FXN57_RS08465 (FXN57_08460)	1634426..1635382	+	957	WP_148327348.1	polysaccharide pyruvyl transferase family protein	-
FXN57_RS08470 (FXN57_08465)	1635491..1635742	+	252	WP_148325252.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Toxin
FXN57_RS08475 (FXN57_08470)	1635739..1635993	+	255	WP_148325251.1	Txe/YoeB family addiction module toxin	Antitoxin
FXN57_RS08480 (FXN57_08475)	1636006..1636749	+	744	WP_148325250.1	YdcF family protein	-
FXN57_RS08485 (FXN57_08480)	1636926..1637753	+	828	WP_148325249.1	DNA ligase	-
FXN57_RS08490 (FXN57_08485)	1637886..1640060	-	2175	WP_148327347.1	DNA helicase II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1631943..1632710	767

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (1-84)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9378.66 Da
• Isoelectric Point: 5.0637

>T136925 WP_148325252.1 NZ_CP043005:1635491-1635742 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLAAIDQLNSGKIIERE
LQE

Nucleotide

• Length: 252 bp

>T136925 NZ_CP043005:1635491-1635742 [Aggregatibacter actinomycetemcomitans]
ATGAATGTAATAAGTTATTCTGCATTCCGTGCAGAATTAGCAACAACACTTGATCAGGTGGTTGCAGATCATAGCCCAGT
CATGATTACCAGACAAAATGGCAAACACGCTGTTGTAATGAGTTTAGAAGATTTCGCAGCTTACGAAGAAACGGCTTATT
TATTACGTAGTCCAAAAAATAGAGAGCGTTTATTAGCCGCTATTGACCAGCTCAATTCAGGTAAAATCATCGAACGGGAA
CTCCAGGAATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 10216.77 Da
• Isoelectric Point: 9.7542

>AT136925 WP_148325251.1 NZ_CP043005:1635739-1635993 [Aggregatibacter actinomycetemcomitans]
MILAWTKTAWEDYLYWQQVDKKTLLRINKLIQNITRSPFEGLGNPEPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Nucleotide

• Length: 255 bp

>AT136925 NZ_CP056314:c4555776-4555435 [Citrobacter freundii]
ATGAAACAGGCAACCAGAAAACCAACGACTGTGGGTGATATCCTGCAATATGAATACCTGGAGCCGCTCGGACTGAAAAT
TAACGATCTGGCTGAAATACTGCATGTTCATCGCAATACGGTGAGCGCACTGGTCAACAATAATCGCAAATTAACAACGG
ATATGGCGTTTCGTTTGGCCAAAGCGTTCGATACCTCCGTTGATTTCTGGCGTAACTTACAGGCGGCGGTTGACCTGTGG
GAAGTTGAAAATGACATGCGGGCGCAAGAAGAACTGAACCGCATTGTTTCGGTTAAAGATTTTATCGCTCAGCGAAATAG
CGAGTCTAAAAAAGTCGCCTGA