Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 1604924..1605516 Replicon chromosome
Accession NZ_CP043005
Organism Aggregatibacter actinomycetemcomitans strain PN_696

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FXN57_RS08310 Protein ID WP_005542431.1
Coordinates 1605217..1605516 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FXN57_RS08305 Protein ID WP_005542432.1
Coordinates 1604924..1605220 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN57_RS08290 (FXN57_08285) 1600428..1602587 - 2160 WP_148363493.1 TonB-dependent siderophore receptor -
FXN57_RS08295 (FXN57_08290) 1602853..1604250 - 1398 WP_148363494.1 MATE family efflux transporter -
FXN57_RS08300 (FXN57_08295) 1604277..1604891 + 615 WP_148325274.1 riboflavin synthase subunit alpha -
FXN57_RS08305 (FXN57_08300) 1604924..1605220 - 297 WP_005542432.1 putative addiction module antidote protein Antitoxin
FXN57_RS08310 (FXN57_08305) 1605217..1605516 - 300 WP_005542431.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FXN57_RS08315 (FXN57_08310) 1605684..1605986 + 303 WP_005545243.1 ribosome assembly RNA-binding protein YhbY -
FXN57_RS08320 (FXN57_08315) 1606062..1606538 - 477 WP_148363495.1 transcription elongation factor GreA -
FXN57_RS08325 (FXN57_08320) 1606697..1608139 + 1443 WP_148327289.1 serine-type D-Ala-D-Ala carboxypeptidase -
FXN57_RS08330 (FXN57_08325) 1608240..1608896 - 657 WP_148325271.1 GTP cyclohydrolase I FolE -
FXN57_RS08335 (FXN57_08330) 1609025..1610239 + 1215 WP_148363496.1 molybdopterin molybdotransferase MoeA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11407.47 Da        Isoelectric Point: 10.4825

>T136924 WP_005542431.1 NZ_CP043005:c1605516-1605217 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

>T136924 NZ_CP043005:c1605516-1605217 [Aggregatibacter actinomycetemcomitans]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAAAAACTCAAAAACCTAAGAGCTAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATGAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCTTGCTTTGTGGCGGAGATAAA
TCCACTCAAGAGAAAGATATTAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10852.32 Da        Isoelectric Point: 4.3776

>AT136924 WP_005542432.1 NZ_CP043005:c1605220-1604924 [Aggregatibacter actinomycetemcomitans]
MSEQLKNFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARARNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Download         Length: 297 bp

>AT136924 NZ_CP043005:c1605220-1604924 [Aggregatibacter actinomycetemcomitans]
ATGAGTGAACAATTGAAAAATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCAGCTTTATTTAAATGAAGT
GCTACAGGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATTGCACGAGCCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTATGCTTCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References