Detailed information of TA system TA136923

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-PumB/upstrm_HI1419-dnstrm_HI1420
• Location: 1357972..1358569
• Replicon: chromosome
• Accession: NZ_CP043005
• Organism: Aggregatibacter actinomycetemcomitans strain PN_696

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FXN57_RS07045
• Protein ID: WP_148325441.1
• Coordinates: 1357972..1358274 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: G4A710
• Locus tag: FXN57_RS07050
• Protein ID: WP_005556438.1
• Coordinates: 1358276..1358569 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXN57_RS07025 (FXN57_07020)	1352974..1354413	-	1440	WP_148325440.1	glycogen synthase GlgA	-
FXN57_RS07030 (FXN57_07025)	1354552..1354947	-	396	Protein_1352	hypothetical protein	-
FXN57_RS07035 (FXN57_07030)	1355039..1355806	+	768	WP_148363065.1	IS5 family transposase	-
FXN57_RS07040 (FXN57_07035)	1355873..1357819	-	1947	WP_148363433.1	ABC transporter ATP-binding protein	-
FXN57_RS07045 (FXN57_07040)	1357972..1358274	+	303	WP_148325441.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FXN57_RS07050 (FXN57_07045)	1358276..1358569	+	294	WP_005556438.1	putative addiction module antidote protein	Antitoxin
FXN57_RS07055 (FXN57_07050)	1358606..1359958	-	1353	WP_148363435.1	anti-phage deoxyguanosine triphosphatase	-
FXN57_RS07060 (FXN57_07055)	1359960..1360652	-	693	WP_148325443.1	CidB/LrgB family autolysis modulator	-
FXN57_RS07065 (FXN57_07060)	1360652..1361062	-	411	WP_148325444.1	CidA/LrgA family protein	-
FXN57_RS07070 (FXN57_07065)	1361242..1362009	+	768	WP_148323191.1	IS5-like element ISAac2 family transposase	-
FXN57_RS07075 (FXN57_07070)	1362027..1362167	-	141	WP_257797246.1	hypothetical protein	-
FXN57_RS07080 (FXN57_07075)	1362297..1363279	+	983	Protein_1362	HlyD family efflux transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1355039..1355806	767
	-	flank	IS/Tn	-	-	1361242..1362009	767

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-89)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11399.99 Da
• Isoelectric Point: 8.3464

>T136923 WP_148325441.1 NZ_CP043005:1357972-1358274 [Aggregatibacter actinomycetemcomitans]
MYIIEETEEFSNWLENLTDELAIVNIVARIGRAKLGNFGDHKSVGNGVYEMRITKGKGYRIYYARKGDITYLLILGGDKS
SQEKDIKNAKALWQQIKNGE

Nucleotide

• Length: 303 bp

>T136923 NZ_CP056314:3723109-3723327 [Citrobacter freundii]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10694.39 Da
• Isoelectric Point: 6.3545

>AT136923 WP_005556438.1 NZ_CP043005:1358276-1358569 [Aggregatibacter actinomycetemcomitans]
MTVTTREFDAARYLKNEKMMAMYLETVLEEGTTAEFIQALNTVARAKGMSELAEKTGIGRESLYKTLSSEKPRFDTILKI
ISALGLSLSINAKDAVA

Nucleotide

• Length: 294 bp

>AT136923 NZ_CP043005:1358276-1358569 [Aggregatibacter actinomycetemcomitans]
ATGACAGTAACAACCCGAGAATTTGATGCAGCGCGTTATTTGAAAAATGAAAAAATGATGGCAATGTATCTTGAAACAGT
TTTAGAAGAAGGCACAACGGCTGAGTTTATACAAGCGCTGAATACGGTCGCAAGAGCAAAGGGAATGTCGGAACTGGCGG
AAAAAACCGGCATCGGACGTGAAAGTTTGTACAAAACCCTATCAAGTGAAAAACCACGTTTTGACACGATTCTAAAAATT
ATTTCAGCATTGGGGCTTAGCCTTTCTATTAATGCTAAAGATGCAGTAGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A142FXE9