Detailed information of TA system TA136922

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1301900..1302435
• Replicon: chromosome
• Accession: NZ_CP043005
• Organism: Aggregatibacter actinomycetemcomitans strain PN_696

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FXN57_RS06815
• Protein ID: WP_019518289.1
• Coordinates: 1301900..1302184 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FXN57_RS06820
• Protein ID: WP_005574425.1
• Coordinates: 1302181..1302435 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXN57_RS06790 (FXN57_06785)	1297273..1299249	+	1977	WP_148325453.1	exodeoxyribonuclease V subunit alpha	-
FXN57_RS06795 (FXN57_06790)	1299262..1299858	+	597	WP_148363405.1	class I SAM-dependent methyltransferase	-
FXN57_RS06800 (FXN57_06795)	1300102..1300530	+	429	WP_005546126.1	50S ribosomal protein L13	-
FXN57_RS06805 (FXN57_06800)	1300547..1300939	+	393	WP_005542159.1	30S ribosomal protein S9	-
FXN57_RS06810 (FXN57_06805)	1301102..1301887	+	786	WP_148363406.1	tRNA pseudouridine(38-40) synthase TruA	-
FXN57_RS06815 (FXN57_06810)	1301900..1302184	-	285	WP_019518289.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FXN57_RS06820 (FXN57_06815)	1302181..1302435	-	255	WP_005574425.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FXN57_RS06825 (FXN57_06820)	1302652..1304109	-	1458	WP_148325451.1	DASS family sodium-coupled anion symporter	-
FXN57_RS06830 (FXN57_06825)	1304336..1305115	+	780	WP_148325450.1	MmcQ/YjbR family DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (18-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11203.22 Da
• Isoelectric Point: 10.6072

>T136922 WP_019518289.1 NZ_CP043005:c1302184-1301900 [Aggregatibacter actinomycetemcomitans]
MSYIIEFIPSSEKEFRKLDINLRKQFIEKLKERAENPRVSSAKLHGMKDCYKIKLRNVGYHLVYQVIDERIVVKVISVGK
RDRNFVYTKAKSRL

Nucleotide

• Length: 285 bp

>T136922 NZ_CP043005:c1302184-1301900 [Aggregatibacter actinomycetemcomitans]
ATGAGTTACATCATTGAGTTTATCCCATCATCTGAAAAAGAATTCCGCAAACTCGATATTAATCTGCGTAAACAATTCAT
TGAGAAATTAAAAGAACGCGCCGAAAATCCCCGAGTGTCATCCGCCAAATTACACGGCATGAAAGATTGCTATAAAATCA
AATTACGCAATGTAGGGTATCATTTGGTGTATCAGGTTATTGATGAACGCATTGTGGTCAAAGTCATCTCCGTAGGAAAA
CGCGATCGAAATTTTGTTTATACCAAAGCAAAAAGCAGGCTTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9462.91 Da
• Isoelectric Point: 4.1191

>AT136922 WP_005574425.1 NZ_CP043005:c1302435-1302181 [Aggregatibacter actinomycetemcomitans]
MTSLVLTDVVASITELKTNPMAVLREAGGKPLAILNRNEPAFYCVPPAIYEYLMELVDDAELTKIVEERQHEKSYPVDLE
DLLQ

Nucleotide

• Length: 255 bp

>AT136922 NZ_CP043005:c1302435-1302181 [Aggregatibacter actinomycetemcomitans]
ATGACAAGCCTTGTTTTAACCGATGTTGTCGCCAGTATCACCGAATTAAAAACTAATCCCATGGCGGTACTTCGTGAAGC
CGGTGGAAAACCGCTGGCAATTTTAAACCGCAATGAACCCGCATTTTATTGCGTCCCACCGGCAATTTATGAATATTTGA
TGGAATTAGTCGATGATGCTGAATTGACAAAAATCGTGGAAGAACGTCAACATGAAAAAAGTTATCCTGTTGATTTAGAG
GATTTACTACAATGA