Detailed information of TA system TA136920

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 2163377..2164039
• Replicon: chromosome
• Accession: NZ_CP043004
• Organism: Aggregatibacter actinomycetemcomitans strain HK_973

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FXN59_RS11245
• Protein ID: WP_148327069.1
• Coordinates: 2163377..2163769 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FXN59_RS11250
• Protein ID: WP_148327070.1
• Coordinates: 2163773..2164039 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXN59_RS11210 (FXN59_11210)	2159319..2160509	-	1191	WP_148327066.1	cystathionine beta-lyase	-
FXN59_RS11215 (FXN59_11215)	2160764..2161321	+	558	WP_005541115.1	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase	-
FXN59_RS11230 (FXN59_11230)	2161744..2162337	+	594	WP_151294955.1	ParA family protein	-
FXN59_RS11235 (FXN59_11235)	2162523..2162897	+	375	WP_262404563.1	conjugal transfer protein TraG N-terminal domain-containing protein	-
FXN59_RS11240 (FXN59_11240)	2162966..2163310	-	345	WP_151294959.1	hypothetical protein	-
FXN59_RS11245 (FXN59_11245)	2163377..2163769	-	393	WP_148327069.1	type II toxin-antitoxin system VapC family toxin	Toxin
FXN59_RS11250 (FXN59_11250)	2163773..2164039	-	267	WP_148327070.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FXN59_RS11255 (FXN59_11255)	2164123..2164518	-	396	WP_262404564.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FXN59_RS11260 (FXN59_11260)	2164469..2164723	-	255	WP_005577690.1	hypothetical protein	-
FXN59_RS11270 (FXN59_11270)	2165040..2165720	+	681	WP_262404565.1	hypothetical protein	-
FXN59_RS11275 (FXN59_11275)	2166247..2166807	-	561	WP_151294961.1	cytolethal distending toxin subunit Aa-CdtC	-
FXN59_RS11280 (FXN59_11280)	2166818..2167669	-	852	WP_148327073.1	cytolethal distending toxin nuclease subunit Aa-CdtB	-
FXN59_RS11285 (FXN59_11285)	2167685..2168353	-	669	WP_148327074.1	cytolethal distending toxin subunit Aa-CdtA	-
FXN59_RS11290 (FXN59_11290)	2168652..2168942	-	291	WP_148327075.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-116)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14932.26 Da
• Isoelectric Point: 5.1083

>T136920 WP_148327069.1 NZ_CP043004:c2163769-2163377 [Aggregatibacter actinomycetemcomitans]
MYMLDTNTVSYFFRQVPVIVNRLNVAGYTQICVSSVTAAELIYGIEKRQNRQLRESVTLFLDTVPVYEWDLSVAITYGKL
RNKMEINGRIMGDLDLMIASHALHLEHTLITNDKAFFMVPGLDVENWLTD

Nucleotide

• Length: 393 bp

>T136920 NZ_CP056314:2030134-2030237 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10304.61 Da
• Isoelectric Point: 5.1970

>AT136920 WP_148327070.1 NZ_CP043004:c2164039-2163773 [Aggregatibacter actinomycetemcomitans]
MERTAKLFRNGRNQAVRLPVEFEFDAEQVYVRKEQNGDIVLSLTSSREASWQRLFKLLPEIKNCDDFLSKEERNQTITTR
DPFPGIGE

Nucleotide

• Length: 267 bp

>AT136920 NZ_CP056314:c2030240-2030099 [Citrobacter freundii]
GATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGG
CATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT