Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1917968..1918502 Replicon chromosome
Accession NZ_CP043004
Organism Aggregatibacter actinomycetemcomitans strain HK_973

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FXN59_RS09975 Protein ID WP_151294848.1
Coordinates 1918212..1918502 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FXN59_RS09970 Protein ID WP_005545663.1
Coordinates 1917968..1918222 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN59_RS09940 (FXN59_09940) 1913696..1914793 + 1098 WP_151294844.1 histidinol-phosphate transaminase -
FXN59_RS09945 (FXN59_09945) 1914804..1916135 + 1332 WP_148326463.1 3-phosphoshikimate 1-carboxyvinyltransferase -
FXN59_RS09950 (FXN59_09950) 1916223..1916690 - 468 WP_148326462.1 ribonuclease HI -
FXN59_RS09955 (FXN59_09955) 1916758..1917519 + 762 WP_151294846.1 DNA polymerase III subunit epsilon -
FXN59_RS09970 (FXN59_09970) 1917968..1918222 + 255 WP_005545663.1 stability protein StbD Antitoxin
FXN59_RS09975 (FXN59_09975) 1918212..1918502 + 291 WP_151294848.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FXN59_RS09980 (FXN59_09980) 1918564..1918902 - 339 WP_148325092.1 cupin domain-containing protein -
FXN59_RS09985 (FXN59_09985) 1919241..1920302 + 1062 WP_148325091.1 YedE family putative selenium transporter -
FXN59_RS09990 (FXN59_09990) 1920474..1921862 + 1389 WP_148326458.1 tRNA 5-hydroxyuridine modification protein YegQ -
FXN59_RS09995 (FXN59_09995) 1922159..1923250 + 1092 WP_151294850.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11568.36 Da        Isoelectric Point: 10.5232

>T136919 WP_151294848.1 NZ_CP043004:1918212-1918502 [Aggregatibacter actinomycetemcomitans]
MTYKLTFDKRALKEWEKLDDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Download         Length: 291 bp

>T136919 NZ_CP056314:808987-809394 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGTTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCTGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9294.53 Da        Isoelectric Point: 3.9649

>AT136919 WP_005545663.1 NZ_CP043004:1917968-1918222 [Aggregatibacter actinomycetemcomitans]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNRNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Download         Length: 255 bp

>AT136919 NZ_CP043004:1917968-1918222 [Aggregatibacter actinomycetemcomitans]
ATGGCAATACATCAAATTTTGACACAGCAAGCCGCAAGCATTACCGATTTAAAACGGGACCCTATGGGTATTGCGTACGC
AAGCCAAGATGGTGCCGTAGCCATATTAAACCGTAACCAACCTGCCTTTTATTGCGTCACGCCTGCATTATTTGAATATT
TTCAAAATCTGGTAGAAGATGCAGAATTAGGCAGAATTGCTGAAGAGCGTCTGGCAACCCTTGATCCGATTGAGGTAAGC
CTCGATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References