Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1884575..1885125 Replicon chromosome
Accession NZ_CP043004
Organism Aggregatibacter actinomycetemcomitans strain HK_973

Toxin (Protein)


Gene name relE Uniprot ID G4A7B4
Locus tag FXN59_RS09810 Protein ID WP_005539226.1
Coordinates 1884859..1885125 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID X2JQ67
Locus tag FXN59_RS09805 Protein ID WP_005539223.1
Coordinates 1884575..1884847 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN59_RS09765 (FXN59_09765) 1880452..1881093 + 642 WP_005546457.1 cytochrome c biogenesis protein CcdA -
FXN59_RS09770 (FXN59_09770) 1881108..1881590 + 483 WP_005552667.1 redoxin family protein -
FXN59_RS09780 (FXN59_09780) 1881947..1882081 - 135 WP_005544187.1 hypothetical protein -
FXN59_RS09785 (FXN59_09785) 1882088..1882291 - 204 WP_005544186.1 IS3 family transposase -
FXN59_RS09790 (FXN59_09790) 1882419..1882592 + 174 WP_005552670.1 hypothetical protein -
FXN59_RS09795 (FXN59_09795) 1882968..1884320 + 1353 WP_151294834.1 anaerobic C4-dicarboxylate transporter DcuC -
FXN59_RS09805 (FXN59_09805) 1884575..1884847 + 273 WP_005539223.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FXN59_RS09810 (FXN59_09810) 1884859..1885125 + 267 WP_005539226.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
FXN59_RS09815 (FXN59_09815) 1885157..1886716 + 1560 WP_061886310.1 glutamine-hydrolyzing GMP synthase -
FXN59_RS09820 (FXN59_09820) 1887109..1888059 - 951 WP_148326473.1 hypothetical protein -
FXN59_RS09825 (FXN59_09825) 1888253..1888666 - 414 WP_032996591.1 hydroxyisourate hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-88)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10502.03 Da        Isoelectric Point: 7.2393

>T136918 WP_005539226.1 NZ_CP043004:1884859-1885125 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLVLIYKIEADTLYFARL
NSHSEVFK

Download         Length: 267 bp

>T136918 NZ_CP043004:1884859-1885125 [Aggregatibacter actinomycetemcomitans]
ATGGATTACGTTTTATCAAAAGAATATAAACGGGACTTAAAAAAACTTCCGGTCGAAATTCAATCCGGTCCGGAATATGC
AGAGGTTTTATATTGCCTGTTCAATCAAAAATCCCTACCCGAACGATATAAAGATCATGCTTTGCAAGGAAATTGGCAGG
GATTTCGAGATTGCCACATCAAAAATGATCTCGTTTTAATTTACAAAATAGAAGCAGACACCCTCTATTTTGCAAGGCTA
AATTCTCACTCGGAAGTGTTTAAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10147.52 Da        Isoelectric Point: 6.2633

>AT136918 WP_005539223.1 NZ_CP043004:1884575-1884847 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Download         Length: 273 bp

>AT136918 NZ_CP043004:1884575-1884847 [Aggregatibacter actinomycetemcomitans]
ATGTTAGATAGCGCAGTGAATTTCCGTACTCAAGCCGACATCAAAGAGCAAGCGTTTAACGTCATTAAAAGCTATGGCTT
AACGCCCGCTCAGGTGTTAAATATGTTTTTGACCCAAATTGCCAAAACCAACACAATTCCGCTCAGTTTGGATTATCAGC
CGAATACAAAAACAGCTAATGCAATCAATGAATTAATGAGCGGAAAAGGGGAAAGATTTAGCGTAGATTCCTTTGATGAA
TTTCAACAAAAAATTCGTGATTTAAGCAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FY83

Antitoxin

Source ID Structure
AlphaFold DB X2JQ67

References