Detailed information of TA system TA136917

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-PumB/upstrm_HI1419-dnstrm_HI1420
• Location: 1581373..1581970
• Replicon: chromosome
• Accession: NZ_CP043004
• Organism: Aggregatibacter actinomycetemcomitans strain HK_973

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FXN59_RS08235
• Protein ID: WP_148325441.1
• Coordinates: 1581668..1581970 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: G4A710
• Locus tag: FXN59_RS08230
• Protein ID: WP_005556438.1
• Coordinates: 1581373..1581666 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXN59_RS08195 (FXN59_08195)	1576719..1576997	+	279	WP_148327599.1	hypothetical protein	-
FXN59_RS08200 (FXN59_08200)	1576997..1577239	+	243	WP_148327598.1	DNA-binding transcriptional regulator	-
FXN59_RS08205 (FXN59_08205)	1577302..1578303	-	1002	WP_148327597.1	site-specific integrase	-
FXN59_RS08215 (FXN59_08215)	1578880..1579290	+	411	WP_148325444.1	CidA/LrgA family protein	-
FXN59_RS08220 (FXN59_08220)	1579290..1579982	+	693	WP_148327596.1	CidB/LrgB family autolysis modulator	-
FXN59_RS08225 (FXN59_08225)	1579984..1581336	+	1353	WP_151294669.1	anti-phage deoxyguanosine triphosphatase	-
FXN59_RS08230 (FXN59_08230)	1581373..1581666	-	294	WP_005556438.1	putative addiction module antidote protein	Antitoxin
FXN59_RS08235 (FXN59_08235)	1581668..1581970	-	303	WP_148325441.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FXN59_RS08240 (FXN59_08240)	1582123..1584069	+	1947	WP_151294671.1	ABC transporter ATP-binding protein	-
FXN59_RS12160	1584337..1584486	+	150	WP_187386994.1	hypothetical protein	-
FXN59_RS12165	1584488..1585102	+	615	WP_187386995.1	hypothetical protein	-
FXN59_RS12600	1585087..1585599	+	513	WP_233444100.1	glycoside hydrolase family 19 protein	-
FXN59_RS08255 (FXN59_08255)	1585741..1586523	+	783	WP_233444098.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-89)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11399.99 Da
• Isoelectric Point: 8.3464

>T136917 WP_148325441.1 NZ_CP043004:c1581970-1581668 [Aggregatibacter actinomycetemcomitans]
MYIIEETEEFSNWLENLTDELAIVNIVARIGRAKLGNFGDHKSVGNGVYEMRITKGKGYRIYYARKGDITYLLILGGDKS
SQEKDIKNAKALWQQIKNGE

Nucleotide

• Length: 303 bp

>T136917 NZ_CP043004:c1581970-1581668 [Aggregatibacter actinomycetemcomitans]
ATGTATATAATTGAGGAAACGGAGGAATTCTCCAACTGGTTAGAGAATCTAACCGACGAACTTGCGATTGTGAATATTGT
CGCTCGAATTGGACGGGCAAAACTCGGTAATTTCGGCGATCATAAATCGGTGGGTAATGGCGTATATGAAATGCGAATTA
CAAAAGGGAAAGGATACAGAATCTACTATGCAAGAAAAGGAGATATTACTTATTTATTAATTCTTGGCGGCGATAAATCA
AGCCAAGAAAAAGATATTAAGAATGCAAAAGCACTATGGCAACAAATTAAAAACGGAGAATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10694.39 Da
• Isoelectric Point: 6.3545

>AT136917 WP_005556438.1 NZ_CP043004:c1581666-1581373 [Aggregatibacter actinomycetemcomitans]
MTVTTREFDAARYLKNEKMMAMYLETVLEEGTTAEFIQALNTVARAKGMSELAEKTGIGRESLYKTLSSEKPRFDTILKI
ISALGLSLSINAKDAVA

Nucleotide

• Length: 294 bp

>AT136917 NZ_CP043004:c1581666-1581373 [Aggregatibacter actinomycetemcomitans]
ATGACAGTAACAACCCGAGAATTTGATGCAGCGCGTTATTTGAAAAATGAAAAAATGATGGCAATGTATCTTGAAACAGT
TTTAGAAGAAGGCACAACGGCTGAGTTTATACAAGCGCTGAATACGGTCGCAAGAGCAAAGGGAATGTCGGAACTGGCGG
AAAAAACCGGCATCGGACGTGAAAGTTTGTACAAAACCCTATCAAGTGAAAAACCACGTTTTGACACGATTCTAAAAATT
ATTTCAGCATTGGGGCTTAGCCTTTCTATTAATGCTAAAGATGCAGTAGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A142FXE9