Detailed information of TA system TA136916

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1562114..1562649
• Replicon: chromosome
• Accession: NZ_CP043004
• Organism: Aggregatibacter actinomycetemcomitans strain HK_973

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FXN59_RS08110
• Protein ID: WP_148327191.1
• Coordinates: 1562114..1562398 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FXN59_RS08115
• Protein ID: WP_005574425.1
• Coordinates: 1562395..1562649 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXN59_RS08085 (FXN59_08085)	1557484..1559463	+	1980	WP_148327193.1	exodeoxyribonuclease V subunit alpha	-
FXN59_RS08090 (FXN59_08090)	1559476..1560072	+	597	WP_005546127.1	class I SAM-dependent methyltransferase	-
FXN59_RS08095 (FXN59_08095)	1560316..1560744	+	429	WP_148327192.1	50S ribosomal protein L13	-
FXN59_RS08100 (FXN59_08100)	1560761..1561153	+	393	WP_005542159.1	30S ribosomal protein S9	-
FXN59_RS08105 (FXN59_08105)	1561316..1562101	+	786	WP_005574423.1	tRNA pseudouridine(38-40) synthase TruA	-
FXN59_RS08110 (FXN59_08110)	1562114..1562398	-	285	WP_148327191.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FXN59_RS08115 (FXN59_08115)	1562395..1562649	-	255	WP_005574425.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FXN59_RS08120 (FXN59_08120)	1562866..1564323	-	1458	WP_151294665.1	DASS family sodium-coupled anion symporter	-
FXN59_RS08125 (FXN59_08125)	1564550..1565329	+	780	WP_151294667.1	MmcQ/YjbR family DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11213.26 Da
• Isoelectric Point: 10.6072

>T136916 WP_148327191.1 NZ_CP043004:c1562398-1562114 [Aggregatibacter actinomycetemcomitans]
MSYIIEFIPSSEKEFRKLDINLRKQFIEKLKERAENPRVSSAKLHGMKDCYKIKLRNVGYHLVYQVIDERIVVKVIPVGK
RDRNFVYTKAKSRL

Nucleotide

• Length: 285 bp

>T136916 NZ_CP043004:c1562398-1562114 [Aggregatibacter actinomycetemcomitans]
ATGAGTTACATCATTGAGTTTATCCCATCATCTGAAAAAGAATTCCGCAAACTCGATATTAATCTGCGTAAACAATTCAT
TGAGAAATTAAAAGAACGCGCCGAAAATCCCCGAGTGTCATCCGCCAAATTACACGGCATGAAAGATTGCTATAAAATCA
AATTACGCAATGTAGGGTATCATTTGGTGTATCAGGTTATTGATGAGCGCATTGTGGTCAAAGTCATCCCCGTAGGAAAA
CGCGATCGAAATTTTGTTTATACCAAAGCAAAAAGCAGGCTTTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9462.91 Da
• Isoelectric Point: 4.1191

>AT136916 WP_005574425.1 NZ_CP043004:c1562649-1562395 [Aggregatibacter actinomycetemcomitans]
MTSLVLTDVVASITELKTNPMAVLREAGGKPLAILNRNEPAFYCVPPAIYEYLMELVDDAELTKIVEERQHEKSYPVDLE
DLLQ

Nucleotide

• Length: 255 bp

>AT136916 NZ_CP043004:c1562649-1562395 [Aggregatibacter actinomycetemcomitans]
ATGACAAGCCTTGTTTTAACCGATGTTGTCGCCAGTATCACCGAATTAAAAACTAATCCCATGGCGGTACTTCGTGAAGC
CGGTGGAAAACCGCTGGCAATTTTAAACCGCAATGAACCCGCATTTTATTGCGTCCCACCGGCAATTTATGAATATTTGA
TGGAATTAGTCGATGATGCTGAATTGACAAAAATCGTGGAAGAACGTCAACATGAAAAAAGTTATCCTGTTGATTTAGAG
GATTTACTACAATGA