Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 1287140..1287732 Replicon chromosome
Accession NZ_CP043004
Organism Aggregatibacter actinomycetemcomitans strain HK_973

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FXN59_RS06800 Protein ID WP_005542431.1
Coordinates 1287140..1287439 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag FXN59_RS06805 Protein ID WP_005542432.1
Coordinates 1287436..1287732 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXN59_RS06775 (FXN59_06775) 1282418..1283632 - 1215 WP_148325270.1 molybdopterin molybdotransferase MoeA -
FXN59_RS06780 (FXN59_06780) 1283761..1284417 + 657 WP_148327290.1 GTP cyclohydrolase I FolE -
FXN59_RS06785 (FXN59_06785) 1284518..1285960 - 1443 WP_148327289.1 serine-type D-Ala-D-Ala carboxypeptidase -
FXN59_RS06790 (FXN59_06790) 1286119..1286595 + 477 WP_148325273.1 transcription elongation factor GreA -
FXN59_RS06795 (FXN59_06795) 1286670..1286972 - 303 WP_005545243.1 ribosome assembly RNA-binding protein YhbY -
FXN59_RS06800 (FXN59_06800) 1287140..1287439 + 300 WP_005542431.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FXN59_RS06805 (FXN59_06805) 1287436..1287732 + 297 WP_005542432.1 putative addiction module antidote protein Antitoxin
FXN59_RS06810 (FXN59_06810) 1287765..1288379 - 615 WP_148327288.1 riboflavin synthase subunit alpha -
FXN59_RS06815 (FXN59_06815) 1288406..1289803 + 1398 WP_148327287.1 MATE family efflux transporter -
FXN59_RS06820 (FXN59_06820) 1290069..1292228 + 2160 WP_148328214.1 TonB-dependent siderophore receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11407.47 Da        Isoelectric Point: 10.4825

>T136914 WP_005542431.1 NZ_CP043004:1287140-1287439 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

>T136914 NZ_CP056308:23231-23647 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGGCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCGTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCCGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10852.32 Da        Isoelectric Point: 4.3776

>AT136914 WP_005542432.1 NZ_CP043004:1287436-1287732 [Aggregatibacter actinomycetemcomitans]
MSEQLKNFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARARNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Download         Length: 297 bp

>AT136914 NZ_CP056308:23004-23234 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATTCGGCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References