Detailed information of TA system TA136914

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/COG3657-dnstrm_HI1420
• Location: 1287140..1287732
• Replicon: chromosome
• Accession: NZ_CP043004
• Organism: Aggregatibacter actinomycetemcomitans strain HK_973

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FXN59_RS06800
• Protein ID: WP_005542431.1
• Coordinates: 1287140..1287439 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: FXN59_RS06805
• Protein ID: WP_005542432.1
• Coordinates: 1287436..1287732 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXN59_RS06775 (FXN59_06775)	1282418..1283632	-	1215	WP_148325270.1	molybdopterin molybdotransferase MoeA	-
FXN59_RS06780 (FXN59_06780)	1283761..1284417	+	657	WP_148327290.1	GTP cyclohydrolase I FolE	-
FXN59_RS06785 (FXN59_06785)	1284518..1285960	-	1443	WP_148327289.1	serine-type D-Ala-D-Ala carboxypeptidase	-
FXN59_RS06790 (FXN59_06790)	1286119..1286595	+	477	WP_148325273.1	transcription elongation factor GreA	-
FXN59_RS06795 (FXN59_06795)	1286670..1286972	-	303	WP_005545243.1	ribosome assembly RNA-binding protein YhbY	-
FXN59_RS06800 (FXN59_06800)	1287140..1287439	+	300	WP_005542431.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FXN59_RS06805 (FXN59_06805)	1287436..1287732	+	297	WP_005542432.1	putative addiction module antidote protein	Antitoxin
FXN59_RS06810 (FXN59_06810)	1287765..1288379	-	615	WP_148327288.1	riboflavin synthase subunit alpha	-
FXN59_RS06815 (FXN59_06815)	1288406..1289803	+	1398	WP_148327287.1	MATE family efflux transporter	-
FXN59_RS06820 (FXN59_06820)	1290069..1292228	+	2160	WP_148328214.1	TonB-dependent siderophore receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (4-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (46-90)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11407.47 Da
• Isoelectric Point: 10.4825

>T136914 WP_005542431.1 NZ_CP043004:1287140-1287439 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDEGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Nucleotide

• Length: 300 bp

>T136914 NZ_CP056308:23231-23647 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGGCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCGTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCCGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10852.32 Da
• Isoelectric Point: 4.3776

>AT136914 WP_005542432.1 NZ_CP043004:1287436-1287732 [Aggregatibacter actinomycetemcomitans]
MSEQLKNFDPAEYLSTEEDIQLYLNEVLQENNIELILSALGDIARARNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYAS

Nucleotide

• Length: 297 bp

>AT136914 NZ_CP056308:23004-23234 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATTCGGCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGACGAAGGACGCTTTGAGCCATGA